Population pharmacokinetics, enzyme occupancy, and 24S-hydroxycholesterol modeling of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in healthy adults.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and translational science"
DOI: 10.1111/cts.13517
Abstract: Soticlestat is a first-in-class, selective inhibitor of cholesterol 24-hydroxylase (CH24H), which catabolizes cholesterol to 24S-hydroxycholesterol (24HC) in the brain, in phase III development for Dravet syndrome and Lennox-Gastaut syndrome treatment. This study aimed to develop… read more here.
Keywords: cholesterol hydroxylase; soticlestat; 24s hydroxycholesterol; model ... See more keywords
Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17232
Abstract: OBJECTIVE The formation of 24S-hydroxycholesterol is a brain-specific mechanism of cholesterol catabolism catalysed by cholesterol 24-hydroxylase (CYP46A1 also known as CH24H). CH24H has been implicated in various biological mechanisms whereas pharmacological lowering of 24S-hydroxycholesterol has… read more here.
Keywords: 24s hydroxycholesterol; cholesterol; soticlestat novel; cholesterol hydroxylase ... See more keywords
Orphan Nuclear Receptor RORα Regulates Enzymatic Metabolism of Cerebral 24S-Hydroxycholesterol through CYP39A1 Intronic Response Element Activation
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DOI: 10.3390/ijms21093309
Abstract: Oxysterols, important regulators of cholesterol homeostasis in the brain, are affected by neurodegenerative diseases. Early-onset Alzheimer’s disease is associated with higher levels of circulating brain-derived 24S-hydroxycholesterol (24S-OHC). Conversion of cholesterol to 24S-OHC is mediated by… read more here.
Keywords: cyp39a1; 24s hydroxycholesterol; receptor ror; ror ... See more keywords