Silencing suppressors of Rice black-streaked dwarf virus and Rice stripe virus hijack the 26S proteasome of Laodelphax striatellus to facilitate virus accumulation and transmission.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.6918
Abstract: BACKGROUND Rice black-streaked dwarf virus (RBSDV) is transmitted by small brown planthopper (Laodelphax striatellus, L. striatellus) and causes devastating disease in rice. P9-1 has silencing suppression activity and is the key protein for viroplasm formation… read more here.
Keywords: rice; 26s proteasome; accumulation; virus ... See more keywords
Effect of Sperm 26S Proteasome on Embryo Formation and Development in In Vitro Fertilization
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive Sciences"
DOI: 10.1007/s43032-022-00916-z
Abstract: The aim of this study was to evaluate the effects of sperm proteasome activity on fertilization outcome and embryo development after IVF. Following density gradient centrifugation for IVF purpose, the spermatozoa of 84 infertile patients… read more here.
Keywords: 26s proteasome; development; fertilization; proteasome activity ... See more keywords
Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.07.004
Abstract: SUMMARY The proteasome is the central protease for intracellular protein breakdown. Coordinated binding and hydrolysis of ATP by the six proteasomal ATPase subunits induces conformational changes that drive the unfolding and translocation of substrates into… read more here.
Keywords: conformational landscape; coverage 26s; landscape reveals; expanded coverage ... See more keywords
An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.07.023
Abstract: Poly-ubiquitin chains direct protein substrates to the 26S proteasome, where they are removed by the deubiquitinase Rpn11 during ATP-dependent substrate degradation. Rapid deubiquitination is required for efficient degradation but must be restricted to committed substrates that… read more here.
Keywords: switch; rpn11; 26s proteasome; aaa motor ... See more keywords
Developing a Bimolecular Affinity Purification Strategy to Isolate 26S Proteasome Holocomplexes for Complex-Centric Proteomic Analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c03551
Abstract: The 26S proteasome is a mega-dalton protein complex responsible for intracellular degradation in eukaryotes. It is composed of two subcomplexes: the 20S core particle and the 19S regulatory particle, which form compositionally and structurally heterogeneous… read more here.
Keywords: analysis; 26s proteasome; affinity purification; strategy ... See more keywords
Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02210
Abstract: 1,2,4-Oxadiazole derivatives, a class of Nrf2-ARE activators, exert an extensive therapeutic effect on inflammation, cancer, neurodegeneration, and microbial infection. Among these analogues, DDO-7263 is the most potent Nrf2 activator and used as the core structure… read more here.
Keywords: rpn6; 26s proteasome; oxadiazole derivatives; mechanism ... See more keywords
P53: Stability from the Ubiquitin–Proteasome System and Specific 26S Proteasome Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c04726
Abstract: Protein p53 is degraded by the 26S proteasome, a protein complex that breaks down cellular proteins. Degradation begins with activation of the protein ubiquitin (Ub) by the ubiquitin-activating E1 enzymes, ubiquitin-conjugating E2 enzymes, and ubiquitin… read more here.
Keywords: 26s proteasome; p53 stability; p53; ubiquitin proteasome ... See more keywords
ATPase subunits of the 26S proteasome are important for oocyte maturation in the brown planthopper
Sign Up to like & getrecommendations! Published in 2022 at "Insect Molecular Biology"
DOI: 10.1111/imb.12761
Abstract: The 26S proteasome is the major engine of protein degradation in all eukaryotic cells. Adenosine triphosphatase (ATPase) regulatory subunits (Rpts) are constituents of the proteasome that are involved in the unfolding and translocation of substrate… read more here.
Keywords: 26s proteasome; proteasome; proteasome important; oocyte maturation ... See more keywords
Hepatitis B Virus X Protein Is Stabilized by the Deubiquitinating Enzyme VCPIP1 in a Ubiquitin-Independent Manner by Recruiting the 26S Proteasome Subunit PSMC3
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00611-22
Abstract: HBx is a multifunctional viral oncoprotein that plays an essential role in the viral life cycle and hepatocarcinogenesis. HBx degradation occurs through the ubiquitin-proteasome system (UPS). ABSTRACT Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is… read more here.
Keywords: ubiquitin independent; 26s proteasome; hbx; psmc3 ... See more keywords
A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress
Sign Up to like & getrecommendations! Published in 2017 at "BMC Cancer"
DOI: 10.1186/s12885-017-3530-z
Abstract: BackgroundMantle cell lymphoma (MCL) is a B-cell hemopathy characterized by the t(11;14) translocation and the aberrant overexpression of cyclin D1. This results in an unrestrained cell proliferation. Other genetic alterations are common in MCL cells… read more here.
Keywords: genotoxic stress; cell lines; 26s proteasome; resistance ... See more keywords
The Drosophila TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle
Sign Up to like & getrecommendations! Published in 2018 at "Biology Open"
DOI: 10.1242/bio.029454
Abstract: ABSTRACT The Drosophila Activin signaling pathway employs at least three separate ligands – Activin-β (Actβ), Dawdle (Daw), and Myoglianin (Myo) – to regulate several general aspects of fruit fly larval development, including cell proliferation, neuronal… read more here.
Keywords: daw; adult; adult muscle; muscle ... See more keywords