Additive effects of mGluR2 positive allosteric modulation, mGluR2 orthosteric stimulation and 5-HT2AR antagonism on dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset.
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DOI: 10.1007/s00210-021-02162-7
Abstract: PURPOSE Antagonising serotonin (5-HT) type 2A receptors (5-HT2AR) is an effective strategy to alleviate both dyskinesia and psychosis in Parkinson's disease (PD). We have recently shown that activation of metabotropic glutamate 2 receptors (mGluR2), via… read more here.
Keywords: ht2ar antagonism; emd 281; mglur2; dyskinesia psychosis ... See more keywords
Effect of the selective 5-HT2A receptor antagonist EMD-281,014 on l-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat
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DOI: 10.1007/s00221-018-5390-4
Abstract: Abstractl-3,4-Dihydroxyphenylalanine (l-DOPA) is the most effective therapy for motor symptoms of Parkinson’s disease (PD); however, with repeated administration, as many as 94% of PD patients develop complications such as l-DOPA-induced dyskinesia. We previously demonstrated that… read more here.
Keywords: 014 dopa; emd 281; ht2a receptor; dopa induced ... See more keywords
The highly selective 5-HT2A antagonist EMD-281,014 reduces dyskinesia and psychosis in the l-DOPA-treated parkinsonian marmoset
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DOI: 10.1016/j.neuropharm.2018.06.038
Abstract: ABSTRACT Blockade of serotonin 2A (5‐HT2A) receptors is regarded as an anti‐dyskinetic and anti‐psychotic strategy in Parkinson's disease (PD). However, the 5‐HT2A antagonists tested so far exhibited affinity for other receptors, which might have played… read more here.
Keywords: emd 281; dopa; selective ht2a; 281 014 ... See more keywords
Combined 5-HT2A and mGlu2 modulation for the treatment of dyskinesia and psychosis in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108465
Abstract: Antagonising the serotonin 2A (5-HT2A) receptor is an efficacious way to alleviate dyskinesia and psychosis in Parkinson's disease (PD). However, previous research indicates that there might be a limit to the effects conferred by this… read more here.
Keywords: 281 014; emd 281; dyskinesia psychosis;