Treatment outcomes of chronic-phase chronic myeloid leukemia with resistance and/or intolerance to a 1st-line tyrosine kinase inhibitor in Japan: the results of the New TARGET study 2nd-line
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DOI: 10.1007/s12185-020-02843-8
Abstract: We herein report the results of the New TARGET study 2nd-line, which collected data on patients with chronic-phase (CP) chronic myeloid leukemia (CML) who received a 2nd-line tyrosine kinase inhibitor (TKI) because of resistance and/or… read more here.
Keywords: 2nd line; line; kinase; line tki ... See more keywords
Immuno-oncology therapy in metastatic bladder cancer: a systematic review and network meta-analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2021.103534
Abstract: CONTEXT Three first line and three second-line clinical trials tested the effect of immunotherapy (IO) relative to standard chemotherapy (CT) on overall survival. However, network meta-analysis-based comparisons have not yet been presented. We addressed this… read more here.
Keywords: 2nd line; meta analysis; line; network meta ... See more keywords
Drug Resistance among Adolescents and Young Adults with Virologic Failure of First Line ART and Response to Second Line Treatment.
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DOI: 10.1089/aid.2019.0232
Abstract: INTRODUCTION Barriers to sustainable virologic suppression (VS) of HIV infected adolescents and young adults include drug resistance mutations (DRMs) and limited treatment options which may impact the outcome of 2nd line antiretroviral therapy (ART). METHODS… read more here.
Keywords: young adults; adolescents young; 2nd line; art ... See more keywords
2nd line bevacizumab(BEV) continuation chemotherapy(Cx) beyond early progression for metastatic colorectal cancer(mCRC)
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DOI: 10.1093/annonc/mdz338.042
Abstract: Abstract Background The ML18174 study, which showed benefits of bevacizumab (BEV) continuation beyond progression (BBP) for metastatic colorectal cancer (mCRC), excluded patients (pts) with 1st line PFS shorter than 3 months. Methods The subjects of… read more here.
Keywords: 2nd line; line; continuation; bbp ... See more keywords
OS05.7.A Absence of severe hematological toxicity during first line treatment predicts low chance on severe toxicity during second line alkylating chemotherapy in glioblastoma
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DOI: 10.1093/neuonc/noab180.023
Abstract: Glioblastoma has an infiltrative growth pattern that makes complete resection of the tumor virtually impossible. Sooner or later the tumor progresses, even after aggressive treatment with maximal safe resection, radiotherapy and/or chemotherapy. Hematological toxicity is… read more here.
Keywords: 2nd line; line; hematological toxicity; toxicity ... See more keywords
Impact of Treatment Free Remission (TFR) with Nilotinib in 2nd Line for Chronic Myeloid Leukemia on Savings That May Fund All BCR-ABL Tests in the Brazilian Public Healthcare System during and after Nilotinib Treatment
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DOI: 10.1182/blood-2018-99-119200
Abstract: Objectives: To estimate the savings and opportunity costs of nilotinib considering treatment free remission after 2nd line treatment of chronic myeloid leukemia (CML) with Nilotinib to fund BCR-ABL molecular test under the Brazilian public healthcare… read more here.
Keywords: 2nd line; system; response; treatment ... See more keywords
A multicenter open-label phase II trial to evaluate nivolumab and ipilimumab for 2nd line therapy in elderly patients with advanced esophageal squamous cell cancer (RAMONA)
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DOI: 10.1186/s12885-019-5446-2
Abstract: BackgroundAdvanced esophageal squamous cell cancer (ESCC) is frequently diagnosed in elderly patients. The impact of 2nd line chemotherapy is poorly defined. Recent data demonstrated effectiveness of checkpoint inhibitors in different squamous cell carcinomas. Therefore, we… read more here.
Keywords: 2nd line; trial; line; squamous cell ... See more keywords
Efficacy of fluoropyrimidine-based chemotherapy in patients with advanced biliary cancer after failure of gemcitabine plus cisplatin: Retrospective analysis of 321 patients.
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DOI: 10.1200/jco.2017.35.4_suppl.425
Abstract: 425Background: In advanced biliary tract cancer (BTC), the role of 2nd line chemotherapy after failure of 1st line gemcitabine plus cisplatin (GEMCIS) has not been established. Fluoropyrimidine(FP)-based regimens are widely used as 2nd line treatment… read more here.
Keywords: chemotherapy; 2nd line; gemcitabine plus; line ... See more keywords
Efficacy of 2nd-line chemotherapy in patients with poorly differentiated, high grade extrapulmonary neuroendocrine carcinoma (PD NEC).
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DOI: 10.1200/jco.2018.36.15_suppl.e16162
Abstract: e16162Background: Platinum/etoposide doublet is considered standard 1st-line therapy for PD NEC, however evidence to guide treatment beyond 1st-line regimens is lacking. Second-line small cell lung... read more here.
Keywords: 2nd line; efficacy 2nd; line; chemotherapy patients ... See more keywords
Outcomes and characteristics of patients receiving second-line therapy for advanced pancreatic cancer.
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DOI: 10.1200/jco.2018.36.4_suppl.435
Abstract: 435Background: Recent trials have demonstrated improved outcomes in the 1st-line treatment of advanced pancreatic cancer (APC). However, there is limited randomized data to guide 2nd-line chemotherapy (CT) selection. We aimed to characterize predictors and outcomes… read more here.
Keywords: 2nd line; line; advanced pancreatic; pancreatic cancer ... See more keywords
The effect of TKI therapy and chemotherapy treatment delivery sequence on total progression-free survival in patients with advanced EGFR-mutated NSCLC.
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DOI: 10.3892/ol.2020.11535
Abstract: The present study aimed to evaluate the total progression-free survival (PFS) time of the 1st-line chemotherapy (CHT)/2nd-line tyrosine kinase inhibitor (TKI) and 1st-line TKI/2nd-line CHT therapeutic regimens. Data from patients with non-small-cell lung cancer (NSCLC)… read more here.
Keywords: 2nd line; line; line cht; line tki ... See more keywords