Targeting Nuclear NAD+ Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells
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DOI: 10.3390/cancers12051180
Abstract: Osteosarcoma (OS) is the most common bone tumor in children and adolescents. Modern OS treatment, based on the combination of neoadjuvant chemotherapy (cisplatin + doxorubicin + methotrexate) with subsequent surgical removal of the primary tumor… read more here.
Keywords: nad synthesis; osteosarcoma; osteosarcoma cells; 2os osteosarcoma ... See more keywords