The c.305del3 in IL‐2 gene in Homonoidea theoretically affects IL‐2/IL‐2R&agr; interaction as well as lymphocyte homeostasis
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DOI: 10.1016/j.cyto.2017.11.011
Abstract: HighlightsIL‐2 structural analysis among primates showed c.305del3 in Hominoidea superfamily.The above mentioned deletion led to weaker interaction of human IL‐2 to its receptor relative to ancestral IL‐2.This deletion in IL‐2 showed an evolutionary effect on… read more here.
Keywords: homeostasis; lymphocyte counts; gene homonoidea; deletion ... See more keywords