Caspase independent cleavages of TDP-43 generates 35kD fragment that cause apoptosis of breast cancer cells.
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DOI: 10.1016/j.bbrc.2018.01.190
Abstract: Transactive response DNA-binding protein 43kD (TDP-43) is a major component of tau-negative and ubiquitin-positive inclusions that characterize ALS (amyotrophic lateral sclerosis) and FTLD (frontotemporal lobar degeneration). Due to its central role in neurodegenerative disease pathogenesis,… read more here.
Keywords: apoptosis breast; breast cancer; 35kd fragment; cancer cells ... See more keywords