Human coronavirus 3CL proteases cleave septins and disrupt Hedgehog signaling, causing ciliary dysfunction
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28618
Abstract: Coronaviruses target ciliate cells causing the loss of cilia, acute rhinorrheas, and other ciliopathies. The loss of ciliary function may help the virus infect, replicate, and spread. However, the molecular mechanisms by which coronaviruses cause… read more here.
Keywords: 3cl protease; protease; coronavirus; human coronavirus ... See more keywords
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Medicinal Chemistry"
DOI: 10.1016/j.ejmech.2018.03.004
Abstract: Abstract There are currently no approved vaccines or small molecule therapeutics available for the prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections. MERS-CoV 3CL protease is essential for viral replication; consequently, it… read more here.
Keywords: guided design; structure guided; 3cl protease; mers cov ... See more keywords
Synergistic Effects of Natural Compounds Toward Inhibition of SARS-CoV-2 3CL Protease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00994
Abstract: The biggest challenge in medical management and control of the COVID-19 pandemic is the nonavailability of the treatment molecules. While vaccines and other biotherapeutic products for managing COVID-19 have reached the market, a small-molecule cure… read more here.
Keywords: cov 3cl; inhibition; 3cl protease; sars cov ... See more keywords
Testing Affordable Strategies for the Computational Study of Reactivity in Cysteine Proteases: The Case of SARS-CoV-2 3CL Protease Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Theory and Computation"
DOI: 10.1021/acs.jctc.2c00294
Abstract: Cysteine proteases are an important target for the development of inhibitors that could be used as drugs to regulate the activity of these kinds of enzymes involved in many diseases, including COVID-19. For this reason,… read more here.
Keywords: cysteine proteases; 3cl protease; cov 3cl; study ... See more keywords
Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c00319
Abstract: A series of nondeuterated and deuterated dipeptidyl aldehyde and masked aldehyde inhibitors that incorporate in their structure a conformationally constrained cyclohexane moiety was synthesized and found to potently inhibit severe acute respiratory syndrome coronavirus-2 3CL… read more here.
Keywords: respiratory syndrome; 3cl protease; coronavirus 3cl; syndrome coronavirus ... See more keywords
Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00117
Abstract: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens public health and safety. Despite the rapid global spread of COVID-19 vaccines,… read more here.
Keywords: 3cl protease; discovery 217622; cov 3cl; inhibitor ... See more keywords
S-217622, a 3CL Protease Inhibitor and Clinical Candidate for SARS-CoV-2.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00624
Abstract: The coronavirus disease (COVID-19) pandemic has highlighted the ability of scientists to quickly react to the immense challenge presented to the world. The orally available 3CL protease inhibitor S-217622 is currently progressing through clinical trials… read more here.
Keywords: 3cl protease; protease inhibitor; 217622 3cl; inhibitor clinical ... See more keywords
Versisterol, a new endophytic steroid with 3CL protease inhibitory activity from Avicennia marina (Forssk.) Vierh.
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra00877g
Abstract: A new epoxy ergostane sterol, named versisterol, was isolated from Aspergillus versicolor, an endophytic fungus from Avicennia marina. The structure of the isolated compound was deduced by means of one- and two-dimensional NMR and high-resolution… read more here.
Keywords: 3cl protease; avicennia marina; kcal mol; versisterol new ... See more keywords
An in silico discovery of potential 3CL protease inhibitors of SARS-CoV-2 based upon inactivation of the cysteine 145-Histidine 41 catalytic dyad
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2047108
Abstract: Abstract Coronavirus disease 19 (COVID19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, several countries are at risk of the pandemic caused by this virus. In the absence of any vaccine or… read more here.
Keywords: 3cl protease; drug candidates; drug; sars cov ... See more keywords
Synthesis and SARS-CoV-2 3CL Protease Inhibitory Effects of Oxazolidinone Derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20220033
Abstract: The 3-chymotrypsin-like protease (3CLpro) is an attractive target for the development of anti- SARS (severe acute respiratory syndrome) drugs. In this work, a series of oxazolidinone derivatives 3a-3v were synthesized and their inhibitory activities against… read more here.
Keywords: protease inhibitory; sars cov; synthesis sars; 3cl protease ... See more keywords
Eupatin, a Flavonoid, Inhibits Coronavirus 3CL Protease and Replication
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119211
Abstract: The coronavirus disease 2019 (COVID-19) pandemic has caused more than six million deaths worldwide since 2019. Although vaccines are available, novel variants of coronavirus are expected to appear continuously, and there is a need for… read more here.
Keywords: 3cl protease; inhibits coronavirus; replication; eupatin flavonoid ... See more keywords