The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Medicinal Chemistry"
DOI: 10.1016/j.ejmech.2020.112711
Abstract: Abstract This review fully describes the coronavirus 3CLpro peptidomimetic inhibitors and nonpeptidic small molecule inhibitors developed from 2010 to 2020. Specifically, the structural characteristics, binding modes and SARs of these 3CLpro inhibitors are expounded in… read more here.
Keywords: 2010 2020; development coronavirus; 3clpro inhibitors; coronavirus like ... See more keywords
3CLpro inhibitors: DEL-based molecular generation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1085665
Abstract: Molecular generation (MG) via machine learning (ML) has speeded drug structural optimization, especially for targets with a large amount of reported bioactivity data. However, molecular generation for structural optimization is often powerless for new targets.… read more here.
Keywords: inhibitors del; structural optimization; 3clpro inhibitors; molecular generation ... See more keywords