Abstract TMP27: Par1 Mediates Protective Effect of 3K3K-APC After White Matter Stroke in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Stroke"
DOI: 10.1161/str.51.suppl_1.tmp27
Abstract: 3K3A-APC is a recombinant variant of activated protein C (APC) with > 90% reduced anticoagulant activity but preserved cell signaling activity. Benefical effects are mediated by its antiapoptotic direct neuronal protective and vasculoprotective effects including… read more here.
Keywords: 3k3a apc; white matter; stroke; par1 ... See more keywords
3K3A-Activated Protein C Prevents Microglia Activation, Inhibits NLRP3 Inflammasome and Limits Ocular Inflammation
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DOI: 10.3390/ijms232214196
Abstract: 3K3A-Activated Protein C (APC) is a recombinant variant of the physiological anticoagulant APC with pleiotropic cytoprotective properties albeit without the bleeding risks. The anti-inflammatory activities of 3K3A-APC were demonstrated in multiple preclinical injury models, including… read more here.
Keywords: inflammation; 3k3a apc; ocular inflammation; treatment ... See more keywords