Orthogonal proteogenomic analysis identifies the druggable PA2G4-MYC axis in 3q26 AML
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DOI: 10.1038/s41467-024-48953-3
Abstract: The overexpression of the ecotropic viral integration site-1 gene (EVI1/MECOM) marks the most lethal acute myeloid leukemia (AML) subgroup carrying chromosome 3q26 abnormalities. By taking advantage of the intersectionality of high-throughput cell-based and gene expression… read more here.
Keywords: proteogenomic analysis; orthogonal proteogenomic; identifies druggable; 3q26 aml ... See more keywords
Abstract 6825: Novel therapeutic strategies targeting MECOM rearranged AMLs discovered by unbiased drug screen
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DOI: 10.1158/1538-7445.am2025-6825
Abstract: The MECOM locus at chromosome 3q26.2 encodes for the transcriptional regulator EVI1. In ∼10% of de novo AML, aberrant overexpression of EVI1 is observed. In approximately 50% of these it is due to inv(3)(q21;q26.2) or… read more here.
Keywords: drug screen; aml; 3q26 aml; unbiased drug ... See more keywords