The Δ40p53 isoform inhibits p53-dependent eRNA transcription and enables regulation by signal-specific transcription factors during p53 activation
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DOI: 10.1371/journal.pbio.3001364
Abstract: The naturally occurring Δ40p53 isoform heterotetramerizes with wild-type p53 (WTp53) to regulate development, aging, and stress responses. How Δ40p53 alters WTp53 function remains enigmatic because their co-expression causes tetramer heterogeneity. We circumvented this issue with… read more here.
Keywords: 40p53 isoform; transcription; 40p53 wtp53; p53 activation ... See more keywords