MicroRNA-4516 suppresses proliferative vitreoretinopathy development via negatively regulating OTX1
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DOI: 10.1371/journal.pone.0270526
Abstract: Proliferative vitreoretinopathy (PVR) progression is associated with TGF-β2-induced epithelial–mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells. In cancer cells, miR-4516 downregulates orthodenticle homeobox 1 (OTX1)-mediated cell invasion. Moreover, OTX1 is shown to be involved… read more here.
Keywords: rpe; tgf induced; mir 4516; 4516 suppresses ... See more keywords