A conserved motif liganding the [4Fe–4S] cluster in [4Fe–4S] fumarases prevents irreversible inactivation of the enzyme during hydrogen peroxide stress
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DOI: 10.1016/j.redox.2019.101296
Abstract: Organisms have evolved two different classes of the ubiquitous enzyme fumarase: the [4Fe–4S] cluster-containing class I enzymes are oxidant-sensitive, whereas the class II enzymes are iron-free and therefore oxidant-resistant. When hydrogen peroxide (H2O2) attacks the… read more here.
Keywords: 4fe fumarases; hydrogen peroxide; fumarase; 4fe cluster ... See more keywords