Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC‐202 blocks oncogenic hedgehog‐GLI signaling and overcomes smoothened inhibitor resistance
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31117
Abstract: Aberrant activation of Hedgehog (HH)/GLI signaling is causally involved in numerous human malignancies, including basal cell carcinoma (BCC) and medulloblastoma. HH pathway antagonists targeting smoothened (SMO), an essential effector of canonical HH/GLI signaling, show significant… read more here.
Keywords: inhibitor; 4sc 202; treatment; resistance ... See more keywords
Abstract 3088: Combination of 4SC-202 and IFN-γ restores mature APC phenotype in AML cells
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3088
Abstract: Acute myeloid leukemia (AML) is characterized by a differentiation block resulting in accumulation of immature myeloid cells. Differentiation therapy, e.g. with all-trans retinoic acid (ATRA) has become a part of standard treatment for the acute… read more here.
Keywords: combination 4sc; 4sc 202; 202 ifn; aml cells ... See more keywords
Abstract 4722: 4SC-202 increases immunogenicity of tumor cells, induces infiltration of tumor microenvironment with cytotoxic T cells, and primes tumors for combinations with different cancer immunotherapy approaches
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4722
Abstract: Various histone deacetylases (HDAC) inhibitors were described as beneficially affecting anti-tumoral immune response. Although different HDAC inhibitors were investigated in syngeneic tumor models, their mode of anti-tumoral action (MOA) is not yet fully understood. Here,… read more here.
Keywords: 4sc 202; tumor cells; immunogenicity tumor; cancer ... See more keywords
Metformin Combined with 4SC-202 Inhibited the Migration and Invasion of OSCC via STAT3/TWIST1
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s268851
Abstract: Background Oral squamous cell carcinoma (OSCC), the most common epithelial malignant neoplasm in the head and neck, characterizes with local infiltration and metastasis of lymph nodes. The five-year survival rate of OSCC remains low despite… read more here.
Keywords: stat3; 4sc 202; twist1; invasion ... See more keywords
4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Brain Sciences"
DOI: 10.3390/brainsci7110147
Abstract: This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric… read more here.
Keywords: potential treatment; 4sc 202; medulloblastoma; 202 potential ... See more keywords