Design, synthesis and binding mode of interaction of novel small molecule o-hydroxy benzamides as HDAC3-selective inhibitors with promising antitumor effects in 4T1-Luc breast cancer xenograft model.
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DOI: 10.1016/j.bioorg.2021.105446
Abstract: Histone deacetylase 3 (HDAC3) is one of the most promising targets to develop anticancer therapeutics. In continuation of our quest for selective HDAC3 inhibitors, a series of small molecules having o-hydroxy benzamide as the novel… read more here.
Keywords: 4t1 luc; cancer xenograft; luc breast; hdac3 selective ... See more keywords