Oleanolic acid attenuated diabetic mesangial cell injury by activation of autophagy via miRNA-142-5p/PTEN signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cytotechnology"
DOI: 10.1007/s10616-019-00335-0
Abstract: Oleanolic acid (OA), a potential drug for diabetic nephropathy (DN) treatment was found to downregulate the expression of microRNA (miR). The research aimed to investigate the effect of OA on autophagy mediated through miR-142-5p targeted… read more here.
Keywords: nrk 52e; mir 142; autophagy; 52e cells ... See more keywords
Stevioside inhibits lipopolysaccharide-induced epithelial-to-mesenchymal transition of NRK-52E cells by PPARγ activation
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2039935
Abstract: Abstract Background Stevioside is a natural diterpenoid compound that possesses anti-inflammatory, immunomodulatory, anti-diabetic, anti-hypertensive, and renal protective effects, but its effect on lipopolysaccharide (LPS)-induced epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells, an important immune… read more here.
Keywords: mesenchymal transition; nrk 52e; smad2; epithelial mesenchymal ... See more keywords
Effect of cell cycle synchronization on cadmium-induced apoptosis and necrosis in NRK-52E cells
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1848065
Abstract: ABSTRACT Heavy metal pollution is a problem that cannot be ignored. Due to the prevalence of cadmium in the environment and its harmful effects on humans, cadmium pollution has become a research hotspot recently. The… read more here.
Keywords: cadmium induced; nrk 52e; cell cycle; effect ... See more keywords
Circular RNA circEIF4G2 aggravates renal fibrosis in diabetic nephropathy by sponging miR-218.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.16129
Abstract: Circular RNAs play essential roles in the development of various human diseases. However, how circRNAs are involved in diabetic nephropathy (DN) are not fully understood. Our study aimed to investigate the effects of circRNA circEIF4G2… read more here.
Keywords: fibrosis; circular rna; nrk 52e; mir 218 ... See more keywords
Effects of homeodomain-interacting protein kinase 2 on renal tubular epithelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202006_21520
Abstract: OBJECTIVE To research the role of homeodomain-interacting protein kinase 2 (HIPK2) on the oxidative stress (OS) and apoptosis induced by hypoxia/reoxygenation (H/R) of normal rat kidney-52E (NRK-52E) cells, through the JAK2/STAT3 signaling pathway MATERIALS AND… read more here.
Keywords: homeodomain interacting; nrk 52e; 52e cells; protein kinase ... See more keywords
Suppression of CIP4/Par6 attenuates TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2017.3100
Abstract: Transforming growth factor-β (TGF-β) induces epithelial-mesenchymal transition (EMT) primarily via a Smad-dependent mechanism. However, there are few studies available on TGF-β-induced EMT through the activation of non-canonical pathways. In this study, the Cdc42-interacting protein-4 (CIP4)/partitioning-defective… read more here.
Keywords: nrk 52e; cip4; tgf; expression ... See more keywords