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5HmC-MIQuant: Ultrasensitive quantitative detection of 5-hydroxymethylcytosine in low-input cell-free DNA samples.

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Published in 2019 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.9b04920

Abstract: Cell free DNA (cfDNA)-based biomarkers such as mutation and methylation offer promising non-invasive strategies for disease diagnosis and prognosis. However, besides high-throughput sequencing, there has been no alternative approach to date to detect the epigenetic… read more here.

Keywords: detection; dna; free dna; cell free ... See more keywords