Alterations in Cardiovascular Parameters in 5xFAD Murine Model
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.70138
Abstract: Alzheimer's Disease (AD) is a global health issue, affecting over 6 million people in the United States, with that number expected to increase as the population ages. As a neurodegenerative disorder that affects memory and… read more here.
Keywords: 5xfad mice; 5xfad murine; murine model; cardiovascular parameters ... See more keywords
Interval timing is disrupted in female 5xFAD mice: An indication of altered memory processes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24418
Abstract: Temporal information processing in the seconds‐to‐minutes range is disrupted in patients with Alzheimer's disease (AD). In this study, we investigated the timing behavior of the 5xFAD mouse model of AD in the peak interval (PI)… read more here.
Keywords: 5xfad mice; memory; interval timing; timing disrupted ... See more keywords
Abnormal [18F]NIFENE binding in transgenic 5xFAD mouse model of Alzheimer's disease: In vivo PET/CT imaging studies of α4β2* nicotinic acetylcholinergic receptors and in vitro correlations with Aβ plaques
Sign Up to like & getrecommendations! Published in 2023 at "Synapse"
DOI: 10.1002/syn.22265
Abstract: Since cholinergic dysfunction has been implicated in Alzheimer's disease (AD), the effects of Aβ plaques on nicotinic acetylcholine receptors (nAChRs) α4β2* subtype were studied using the transgenic 5xFAD mouse model of AD. Using the PET… read more here.
Keywords: 18f nifene; 5xfad mice; vivo pet; mice ... See more keywords
Vasoactive Intestinal Peptide Decreases β-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1226-8
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by extracellular deposits of fibrillary β-amyloid (Aβ) plaques in the brain that initiate an inflammatory process resulting in neurodegeneration. The neuronal loss associated with AD results in… read more here.
Keywords: alzheimer disease; 5xfad mice; mouse model; intestinal peptide ... See more keywords
Every-Other-Day Feeding Prevents the Loss of Parvalbumin-Expressing Neurons in the Cerebral Cortex of Female 5xFAD Mice
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurobiology"
DOI: 10.1007/s12035-025-05355-w
Abstract: The present study demonstrates the effects of an every-other-day (EOD) feeding regimen on parvalbumin (PV)-expressing interneurons in the cortex of 5xFAD mice, a well-established animal model of Alzheimer’s disease (AD). Female 5xFAD mice and their… read more here.
Keywords: 5xfad mice; loss; eod feeding; parvalbumin expressing ... See more keywords
Motor function deficits in the 12 month-old female 5xFAD mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.09.009
Abstract: Abstract Motor problems occur early in some patients with Alzheimer’s disease (AD) and as the disease progresses many patients develop motor dysfunction. Motor dysfunction has been reported in some mouse models of AD, including the… read more here.
Keywords: disease; 5xfad mice; motor; mice ... See more keywords
Prolonged isolation stress accelerates the onset of Alzheimer’s disease-related pathology in 5xFAD mice despite running wheels and environmental enrichment
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112366
Abstract: Research has demonstrated that stress can exacerbate AD pathology in transgenic mouse models of AD. The purpose of the present studies was to extend this work by determining whether a social stressor, isolation stress, would… read more here.
Keywords: isolation stress; isolation; 5xfad mice; pathology ... See more keywords
A regional and cellular analysis of the early intracellular and extracellular accumulation of Aβ in the brain of 5XFAD mice
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.135869
Abstract: Intracellular Aβ (iAβ) expression, extracellular Aβ (eAβ) plaque formation and microglial reactivity are characteristic neuropathological events of Alzheimer's disease (AD) and have been detected in several transgenic mouse models of this disease. In this work… read more here.
Keywords: analysis; pathology; regional cellular; 5xfad mice ... See more keywords
Resident brain neural precursor cells develop age-dependent loss of therapeutic functions in Alzheimer's mice
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.07.020
Abstract: There is vast knowledge on pathogenic mechanisms in Alzheimer's disease but very little on means by which the brain protects itself from disease. A major candidate in providing neuroprotection is the resident brain neural precursor/stem… read more here.
Keywords: disease; pathology; 5xfad mice; resident brain ... See more keywords
Inhibition of Hippo Signaling Through Ablation of Lats1 and Lats2 Protects Against Cognitive Decline in 5xFAD Mice via Increasing Neuronal Resilience Against Ferroptosis
Sign Up to like & getrecommendations! Published in 2025 at "Aging Cell"
DOI: 10.1111/acel.70218
Abstract: The Hippo signaling pathway is a key regulator of cell growth and cell survival, and hyperactivation of the Hippo pathway has been implicated in neurodegenerative diseases such as Huntington's disease. However, the role of Hippo… read more here.
Keywords: 5xfad mice; ablation lats1; hippo signaling; lats1 lats2 ... See more keywords
Age‐related deterioration of motor function in male and female 5xFAD mice from 3 to 16 months of age
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.1111/gbb.12538
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder that leads to age‐related cognitive and sensori‐motor dysfunction. There is an increased understanding that motor dysfunction contributes to overall AD severity, and a need to ameliorate these impairments.… read more here.
Keywords: age; 5xfad mice; motor; motor dysfunction ... See more keywords