Interval timing is disrupted in female 5xFAD mice: An indication of altered memory processes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24418
Abstract: Temporal information processing in the seconds‐to‐minutes range is disrupted in patients with Alzheimer's disease (AD). In this study, we investigated the timing behavior of the 5xFAD mouse model of AD in the peak interval (PI)… read more here.
Keywords: 5xfad mice; memory; interval timing; timing disrupted ... See more keywords
Abnormal [18F]NIFENE binding in transgenic 5xFAD mouse model of Alzheimer's disease: In vivo PET/CT imaging studies of α4β2* nicotinic acetylcholinergic receptors and in vitro correlations with Aβ plaques
Sign Up to like & getrecommendations! Published in 2023 at "Synapse"
DOI: 10.1002/syn.22265
Abstract: Since cholinergic dysfunction has been implicated in Alzheimer's disease (AD), the effects of Aβ plaques on nicotinic acetylcholine receptors (nAChRs) α4β2* subtype were studied using the transgenic 5xFAD mouse model of AD. Using the PET… read more here.
Keywords: 18f nifene; 5xfad mice; vivo pet; mice ... See more keywords
Vasoactive Intestinal Peptide Decreases β-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1226-8
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by extracellular deposits of fibrillary β-amyloid (Aβ) plaques in the brain that initiate an inflammatory process resulting in neurodegeneration. The neuronal loss associated with AD results in… read more here.
Keywords: alzheimer disease; 5xfad mice; mouse model; intestinal peptide ... See more keywords
Motor function deficits in the 12 month-old female 5xFAD mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.09.009
Abstract: Abstract Motor problems occur early in some patients with Alzheimer’s disease (AD) and as the disease progresses many patients develop motor dysfunction. Motor dysfunction has been reported in some mouse models of AD, including the… read more here.
Keywords: disease; 5xfad mice; motor; mice ... See more keywords
Prolonged isolation stress accelerates the onset of Alzheimer’s disease-related pathology in 5xFAD mice despite running wheels and environmental enrichment
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112366
Abstract: Research has demonstrated that stress can exacerbate AD pathology in transgenic mouse models of AD. The purpose of the present studies was to extend this work by determining whether a social stressor, isolation stress, would… read more here.
Keywords: isolation stress; isolation; 5xfad mice; pathology ... See more keywords
A regional and cellular analysis of the early intracellular and extracellular accumulation of Aβ in the brain of 5XFAD mice
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.135869
Abstract: Intracellular Aβ (iAβ) expression, extracellular Aβ (eAβ) plaque formation and microglial reactivity are characteristic neuropathological events of Alzheimer's disease (AD) and have been detected in several transgenic mouse models of this disease. In this work… read more here.
Keywords: analysis; pathology; regional cellular; 5xfad mice ... See more keywords
Resident brain neural precursor cells develop age-dependent loss of therapeutic functions in Alzheimer's mice
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.07.020
Abstract: There is vast knowledge on pathogenic mechanisms in Alzheimer's disease but very little on means by which the brain protects itself from disease. A major candidate in providing neuroprotection is the resident brain neural precursor/stem… read more here.
Keywords: disease; pathology; 5xfad mice; resident brain ... See more keywords
Age‐related deterioration of motor function in male and female 5xFAD mice from 3 to 16 months of age
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.1111/gbb.12538
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder that leads to age‐related cognitive and sensori‐motor dysfunction. There is an increased understanding that motor dysfunction contributes to overall AD severity, and a need to ameliorate these impairments.… read more here.
Keywords: age; 5xfad mice; motor; motor dysfunction ... See more keywords
Chemosensory deficits and increased apneas in the 5XFAD mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735203
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease commonly associated with aging. Along with a decline in cognition and memory, individuals with AD often have respiratory disturbances such as sleep apnea, insufficient ventilation during sleep, and… read more here.
Keywords: disease; progression; 5xfad mice; pathology ... See more keywords
Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer’s disease mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01738-z
Abstract: Background Accumulating data suggest a central role for brain microglia in mediating cortical neuronal death in Alzheimer’s disease (AD), and for Toll-like receptor 2 (TLR2) in their toxic activation. Amyloid deposition in preclinical AD is… read more here.
Keywords: tlr2; microbial tlr2; alzheimer disease; 5xfad mice ... See more keywords
Nicotinamide attenuates the decrease in dendritic spine density in hippocampal primary neurons from 5xFAD mice, an Alzheimer’s disease animal model
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Brain"
DOI: 10.1186/s13041-020-0565-x
Abstract: Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by memory loss and the presence of amyloid plaques and neurofibrillary tangles in the patients’ brains. In this study, we investigated the alterations in metabolite… read more here.
Keywords: primary neurons; spine density; hippocampal primary; disease ... See more keywords