Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1266
Abstract: Assembly of ribosomal subunits into active ribosomal complexes is integral to protein synthesis. Release of eIF6 from the 60S ribosomal subunit primes 60S to associate with the 40S subunit and engage in translation. The dynamics… read more here.
Keywords: ribosomal subunit; 60s ribosomal; interface; dynamic states ... See more keywords
Processed pseudogene confounding the identification of a putative lethal recessive deletion in the bovine 60S ribosomal protein L11 gene (uL5).
Sign Up to like & getrecommendations! Published in 2019 at "Animal genetics"
DOI: 10.1111/age.12868
Abstract: Background: In higher eukaryotes, impaired ribosome biogenesis and function can result in specific phenotypes, the so-called ribosomopathies. In humans at least six ribosomopathies have been described, i.e. Diamond–Blackfan anemia (DBA), 5q-syndrome, Shwachman–Diamond syndrome, X-linked dyskeratosis… read more here.
Keywords: 60s ribosomal; protein l11; gene ul5; 129 195 ... See more keywords
Abstract 3719: Targeting the eIF6 and 60S ribosomal subunit interaction interface in cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3719
Abstract: Translational control is integral to cancer initiation and progression. A subset of translation initiation factors are deregulated in cancers to facilitate their rampant growth and proliferation. Eukaryotic translation initiation factor 6 (eIF6) is one such… read more here.
Keywords: interaction interface; interaction; targeting eif6; eif6 60s ... See more keywords
Elucidation of the FKBP25-60S Ribosomal Protein L7a Stress Response Signaling During Ischemic Injury
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DOI: 10.1159/000491470
Abstract: Background/Aims: Peptidyl-prolyl cis-trans isomerase FKBP25 is a member of the FK506-binding proteins family which has peptidyl-prolyl cis/trans isomerase domain. The biological function and pathophysiologic role of FKBP25 remain elusive. Methods: The spatio-temporal changes in expression… read more here.
Keywords: 60s ribosomal; protein l7a; ribosomal protein; fkbp25 ... See more keywords
Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2019 at "RNA"
DOI: 10.1261/rna.072116.119
Abstract: In Saccharomyces cerevisiae more than 250 trans-acting factors are involved in the maturation of 40S and 60S ribosomal subunits. The expression of most of these factors is transcriptionally co-regulated to ensure correct ribosome production under… read more here.
Keywords: 60s ribosomal; saccharomyces cerevisiae; ribosomal subunit; factor required ... See more keywords
The Terminal Extensions of Dbp7 Influence Growth and 60S Ribosomal Subunit Biogenesis in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043460
Abstract: Ribosome synthesis is a complex process that involves a large set of protein trans-acting factors, among them DEx(D/H)-box helicases. These are enzymes that carry out remodelling activities onto RNAs by hydrolysing ATP. The nucleolar DEGD-box… read more here.
Keywords: growth 60s; ribosomal subunit; terminal extensions; biogenesis ... See more keywords