Synthesis and Evaluation of a Novel 64Cu- and 67Ga-Labeled Neurokinin 1 Receptor Antagonist for in Vivo Targeting of NK1R-Positive Tumor Xenografts.
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DOI: 10.1021/acs.bioconjchem.8b00063
Abstract: Neurokinin 1 receptor (NK1R) is expressed in gliomas and neuroendocrine malignancies and represents a promising target for molecular imaging and targeted radionuclide therapy. The goal of this study was to synthesize and evaluate a novel… read more here.
Keywords: targeting nk1r; neurokinin receptor; 67ga labeled; nk1r nota ... See more keywords
Coordination-Mediated Synthesis of 67Ga-Labeled Purification-Free Trivalent Probes for in Vivo Imaging of Saturable Systems.
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DOI: 10.1021/acs.bioconjchem.8b00337
Abstract: A large excess of unlabeled ligands over gallium-67 (67Ga) provides 67Ga-labeled probes with high radiochemical yields in a short reaction time. However, the unlabeled ligands hinder target accumulation of radiolabeled probes by competing for target… read more here.
Keywords: labeled trivalent; trivalent probe; 67ga labeled; trivalent ... See more keywords