Biodistribution, pharmacokinetics, dosimetry of [68Ga]Ga-DOTA.SA.FAPi, and the head-to-head comparison with [18F]F-FDG PET/CT in patients with various cancers
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-05132-y
Abstract: [68Ga]Ga-labeled fibroblast activation protein inhibitors ([68Ga]Ga-FAPi) have shown promising preclinical and clinical results in PET imaging. The present study aimed to evaluate the biodistribution, pharmacokinetics, and dosimetry of [68Ga]Ga-DOTA.SA.FAPi, another modified FAPi tracer, and performed… read more here.
Keywords: various cancers; 68ga dota; dota fapi; 18f fdg ... See more keywords
Synthesis, preclinical evaluation, and a pilot clinical imaging study of [18F]AlF-NOTA-JR11 for neuroendocrine neoplasms compared with [68Ga]Ga-DOTA-TATE
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05249-8
Abstract: A [18F]AlF-labeled somatostatin receptor (SSTR) antagonist was developed for imaging of neuroendocrine neoplasms (NENs), evaluated and compared with [68Ga]Ga-DOTA-TATE. [18F]AlF-NOTA-JR11 was synthesized manually and qualified with high-performance liquid chromatography (HPLC) and liquid chromatography–mass spectrometry (LC-MS).… read more here.
Keywords: 68ga dota; nota jr11; alf nota; 18f alf ... See more keywords
68Ga-DOTA-FAPI-04 PET mimicking whole body bone scan in a patient with metabolic bone disease
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05457-2
Abstract: A 63-year-old male had a history of kidney stones and recurrent hydronephrosis for more than 30 years. He received parathyroidectomy 1.5 years ago because of elevated serum calcium level (3.47 mmol/L, normal range 2.03–2.54 mmol/L)… read more here.
Keywords: fapi pet; 68ga dota; bone; fapi ... See more keywords
Vertebral metastases from neuroendocrine tumours: How to avoid false positives on 68Ga-DOTA-TOC PET using CT pattern analysis?
Sign Up to like & getrecommendations! Published in 2017 at "European Radiology"
DOI: 10.1007/s00330-017-5294-x
Abstract: ObjectivesTo develop criteria to improve discrimination between vertebral metastases from neuroendocrine tumours (NETs) and benign bone lesions on PET combined with CT using DOTA-D-Phe1-Tyr3-octreotide labelled with gallium-68 (68Ga-DOTA-TOC).MethodsIn 535 NET patients, 68Ga-DOTA-TOC PET/CT examinations were… read more here.
Keywords: toc pet; 68ga dota; vertebral metastases; dota toc ... See more keywords
Angiogenesis-Targeted 68Ga-DOTA-RGD2 PET/CT Imaging: a Potential Theranostic Application in the Case of Chondrosarcoma
Sign Up to like & getrecommendations! Published in 2021 at "Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s13139-021-00691-w
Abstract: Chondrosarcoma is a cartilaginous tumor of mesenchymal origin. The histology and grade of the tumor determine the chances of relapse and survival. These tumors usually respond poorly to chemo-radiotherapy in cases of non-resectable and recurrent… read more here.
Keywords: chondrosarcoma; 68ga dota; pet; angiogenesis ... See more keywords
Consensus on molecular imaging and theranostics in neuroendocrine neoplasms.
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DOI: 10.1016/j.ejca.2021.01.008
Abstract: Nuclear medicine plays an increasingly important role in the management neuroendocrine neoplasms (NEN). Somatostatin analogue (SSA)-based positron emission tomography/computed tomography (PET/CT) and peptide receptor radionuclide therapy (PRRT) have been used in clinical trials and approved… read more here.
Keywords: medicine; 68ga dota; consensus; neuroendocrine neoplasms ... See more keywords
A Systematic Investigation into the Influence of Net Charge on the Biological Distribution of Radiometalated Peptides Using [68Ga]Ga-DOTA-TATE Derivatives.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.3c00007
Abstract: Recently, several radiometalated peptides have been approved for clinical imaging and/or therapy (theranostics) of several types of cancer; nonetheless, the primary challenge that most of these peptides confront is significant renal uptake and retention, which… read more here.
Keywords: net charge; tate; dota tate; 68ga dota ... See more keywords
68Ga-Labeled Cystine Knot Peptide Targeting Integrin αvβ6 for Lung Cancer PET Imaging.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00313
Abstract: Integrin αvβ6 has been considered as a promising biomarker for lung cancer, and its expression is often related to poor prognosis. An αvβ6-binding cystine knot peptide R01-MG was previously engineered and validated. Here, we developed… read more here.
Keywords: lung; lung cancer; 68ga dota; dota r01 ... See more keywords
The utility of 18F-FDG and 68Ga-DOTA-Peptide PET/CT in the evaluation of primary pulmonary carcinoid
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DOI: 10.1097/md.0000000000014769
Abstract: Background: Pulmonary carcinoids (PC) are histologically classified into typical carcinoid (TC) and atypical carcinoid (AC). The diagnosis of pulmonary carcinoid and possibly the differentiation between TC and AC could make a significant effect on the… read more here.
Keywords: 68ga dota; carcinoid; 18f fdg; dota peptide ... See more keywords
Peptide-based 68Ga-PET radiotracer for imaging CD133 expression in colorectal cancer
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DOI: 10.1097/mnm.0000000000001435
Abstract: Objective: CD133 is a demonstrated cancer stem cell marker. A small peptide LS7, screened by a phage display technique, was identified to specifically target CD133. The purpose of this study was to develop a novel… read more here.
Keywords: ls7; dota ls7; cd133; 68ga dota ... See more keywords
The 68Ga-DOTA-FAPI-04 PET/CT for the differential diagnosis of solitary fibroma of pleura from other chest disease with low uptake of 18F-FDG
Sign Up to like & getrecommendations! Published in 2022 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001579
Abstract: Objective We conducted a prospective study using 68Ga-DOTA-FAPI-04 PET/computed tomography (CT) to differentiate solitary fibromas of pleura (SFP) from other chest similar masses showing low uptake of 18F-FDG. Methods A prospective study including 13 patients… read more here.
Keywords: uptake 18f; 18f fdg; dota fapi; 68ga dota ... See more keywords