Synthesis and Preclinical Evaluation of a Novel FAPI-04 Dimer for Cancer Theranostics.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00965
Abstract: Overexpression of fibroblast activation protein (FAP) in cancer-associated fibroblasts in a wide variety of tumors enables a highly selective targeting strategy using FAP inhibitors (FAPIs). Quinoline-based FAPIs labeled with radionuclides have been widely developed for… read more here.
Keywords: fapi; novel fapi; fapi dimer; 68ga fapi ... See more keywords
Noninvasive Assessment of Renal Fibrosis of Chronic Kidney Disease in Rats by [68Ga]Ga-FAPI-04 Small Animal PET/CT and Biomarkers.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00163
Abstract: Renal fibrosis is the most common pathological feature and common pathway of progression in chronic kidney disease (CKD). We evaluated [68Ga]Ga-FAPI-04 small animal positron emission tomography/computed tomography (PET/CT) and biomarkers as noninvasive assessments of renal… read more here.
Keywords: small animal; renal fibrosis; group; fapi small ... See more keywords
Using 18F-flurodeoxyglucose and 68Ga-fibroblast activation protein inhibitor PET/CT to evaluate a new periprosthetic joint infection model of rabbit due to Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2022 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001495
Abstract: Supplemental Digital Content is available in the text. Purpose The existing periprosthetic joint infection (PJI) models have obvious limitations, and studies of PJI on animal models using PET/computed tomography (CT) for diagnosis are still lacking.… read more here.
Keywords: periprosthetic joint; joint infection; 18f fdg; model ... See more keywords
Elevated 68Ga-FAPI Activity in Splenic Hemangioma and Pneumonia.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000003638
Abstract: ABSTRACT A 59-year-old woman with newly diagnosed pulmonary nodules underwent both 18F-FDG and 68Ga-FAPI PET/CT. Both studies showed similarly increased uptake in pneumonia. However, only 68Ga-FAPI PET/CT showed increased uptake in splenic hemangioma, whereas FDG… read more here.
Keywords: fapi activity; splenic hemangioma; 68ga fapi; pneumonia ... See more keywords
Chronic Colitis Mimicking Malignancy on 68Ga-FAPI PET/CT.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000003793
Abstract: ABSTRACT A 40-year-old man presented with abdominal pain and diarrhea for 2 months. Abdominal CT showed thickening of the cecal wall, which was considered likely malignant. The patient was subsequently enrolled in a clinical trial… read more here.
Keywords: fapi pet; chronic colitis; 68ga fapi; malignancy ... See more keywords
18F-FDG PET/CT and 68Ga-FAPI-4 PET/CT Findings of Bilateral Knee Osteoarthritis in a Patient With Uveal Malignant Melanoma.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000003854
Abstract: ABSTRACT We present the findings of 68Ga-FAPI-4 PET/CT and 18F-FDG PET/CT of a metastatic malignant melanoma patient with osteoarthritis. A 65-year-old woman with a history of metastatic uveal malignant melanoma was referred to 18F-FDG PET/CT… read more here.
Keywords: malignant melanoma; 18f fdg; fdg pet; 68ga fapi ... See more keywords
68Ga-FAPI PET/CT Findings in a Rare Presacral Myxopapillary Ependymoma.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000003963
Abstract: ABSTRACT Myxopapillary ependymoma is a rare tumor. Most of them occur exclusively in the conus medullaris, cauda equina, or filum terminale. Here, we present the 68Ga-FAPI PET/CT findings in a 37-year-old woman with presacral myxopapillary… read more here.
Keywords: ependymoma; myxopapillary ependymoma; pet findings; fapi pet ... See more keywords
Uterine Uptake of 68Ga-FAPI-04 in Uterine Pathology and Physiology
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000003968
Abstract: Purpose 68Ga-labeled fibroblast activation protein inhibitor (68Ga-FAPI-04) has been useful in the imaging of desmoplastic reaction in different tumors. As we have found that most female patients showed avid uterine uptake of 68Ga-FAPI-04, we sought… read more here.
Keywords: pathology; uterine uptake; uptake 68ga; physiology ... See more keywords
Progressive Multifocal Leukoencephalopathy Mimicking Malignancy on 68Ga-FAPI PET/CT: Potential Advantages of FAPI.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000003976
Abstract: ABSTRACT A 43-year-old man presented with weakness in his right upper limb for 2 months. Head MRI showed intracranial multiple abnormal signal foci. Malignancy was suspected. The patient was subsequently enrolled in the clinical trial… read more here.
Keywords: fapi; multifocal leukoencephalopathy; progressive multifocal; malignancy ... See more keywords
Increased 68Ga-FAPI Uptake in Avascular Necrosis of Femoral Head in a Patient With Nasopharyngeal Carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000003996
Abstract: ABSTRACT A 73-year-old man with newly diagnosed nasopharyngeal carcinoma included in a clinical trial of 68Ga-FAPI PET/CT study in tumors (ChiCTR2100044131). Increased tracer uptake was noted in nasopharyngeal carcinoma and cervical lymph nodes metastases. In… read more here.
Keywords: nasopharyngeal carcinoma; avascular necrosis; femoral head; 68ga fapi ... See more keywords
Differentiation of Reactive Lymph Nodes and Tumor Metastatic Lymph Nodes With 68Ga-FAPI PET/CT in a Patient With Squamous Cell Lung Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000003998
Abstract: ABSTRACT False-positive findings of mediastinal lymph node often confound the image interpretation of the preoperative PET/CT in non-small cell lung cancer. In this case, we reported 18F-FDG and 68Ga-FAPI PET/CT findings in a patient with… read more here.
Keywords: lung cancer; 68ga fapi; lymph nodes; cell lung ... See more keywords