6mer Seed Toxicity in Viral microRNAs
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.11.031
Abstract: Summary MicroRNAs (miRNAs) are short double-stranded noncoding RNAs (19-23 nucleotides) that regulate gene expression by suppressing mRNAs through RNA interference. Targeting is determined by the seed sequence (position 2-7/8) of the mature miRNA. A minimal… read more here.
Keywords: seed; 6mer seed; seed toxicity; viral micrornas ... See more keywords
6mer seed toxicity in tumor suppressive microRNAs
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06526-1
Abstract: Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2–7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer seeds revealing a preference for guanine… read more here.
Keywords: seed; 6mer seed; toxicity; cancer cells ... See more keywords