1MeTIQ and olanzapine, despite their neurochemical impact, did not ameliorate performance in fear conditioning and social interaction tests in an MK-801 rat model of schizophrenia
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DOI: 10.1007/s43440-020-00209-9
Abstract: Background The aim of the present study was to evaluate the effect of 1MeTIQ on fear memory and social interaction in an MK-801-induced model of schizophrenia. The results obtained after administration of 1MeTIQ were compared… read more here.
Keywords: 1metiq olanzapine; fear; 801 induced; model schizophrenia ... See more keywords
Neuroprotective role of taurine on MK-801-induced memory impairment and hyperlocomotion in zebrafish
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DOI: 10.1016/j.neuint.2020.104710
Abstract: Schizophrenia is a neuropsychiatric condition that reaches around 1% of people worldwide. Because taurine exerts a neuroprotective role in the brain, this molecule is a promising candidate to reduce schizophrenia-like symptoms. Here, we investigated a… read more here.
Keywords: 801 induced; induced memory; hyperlocomotion; role ... See more keywords
Neurobehavioral Differences of Valproate and Risperidone on MK-801 Inducing Acute Hyperlocomotion in Mice
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DOI: 10.1155/2022/1048463
Abstract: Objective The glutamate system plays a major role in the development of neuropsychiatric disorders such as addiction, epilepsy, dementia, and psychosis. MK-801 (dizocilpine), an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, could increase locomotor activity and stereotyped… read more here.
Keywords: hyperlocomotion; risperidone valproic; risperidone; valproic acid ... See more keywords
Olanzapine Reverses MK-801-Induced Cognitive Deficits and Region-Specific Alterations of NMDA Receptor Subunits
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DOI: 10.3389/fnbeh.2017.00260
Abstract: Cognitive dysfunction constitutes an essential component in schizophrenia for its early presence in the pathophysiology of the disease and close relatedness to life quality of patients. To develop effective treatment of cognitive deficits, it is… read more here.
Keywords: cognitive deficits; nmda receptor; receptor subunits; 801 induced ... See more keywords
The effects and mechanism of environmental enrichment on MK-801 induced cognitive impairment in rodents with schizophrenia
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DOI: 10.3389/fncel.2022.1024649
Abstract: Schizophrenia is a severe mental disorder characterized by positive, negative, and cognitive symptoms. Cognitive symptoms are a kind of symptoms with high incidence and great impact on patients. There is no effective treatment in clinical… read more here.
Keywords: environmental enrichment; impairment rodents; cognitive impairment; 801 induced ... See more keywords
Sustained MK-801 induced deficit in a novel probabilistic reversal learning task
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.898548
Abstract: Cognitive flexibility, the ability to adapt to unexpected changes, is critical for healthy environmental and social interactions, and thus to everyday functioning. In neuropsychiatric diseases, cognitive flexibility is often impaired and treatment options are lacking.… read more here.
Keywords: time; reversal learning; based prl; probabilistic reversal ... See more keywords