Mechanistic studies of the apoptosis induced by the macrocyclic natural product tetrandrine in MGC 803 cells
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2268-8
Abstract: Tetrandrine (Tet) is a macrocyclic tetrahydroisoquinoline alkaloid isolated from Stephania tetrandra S. Moore along with other Chinese and Japanese herbs. It has been used extensively for the treatment of silicosis, autoimmune disorders, inflammatory diseases and… read more here.
Keywords: mgc 803; gastric cancer; tetrandrine; tet ... See more keywords
Design, synthesis, and preliminary biological evaluation of chrysin amino acid derivatives that induce apoptosis and suppress cell migration
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2019.1597056
Abstract: Abstract Amino acid derivatives containing chrysin were synthesized for evaluating their anticancer effects. Among them, compound N-(7-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)heptanoyl)-L-isoleucine (6e) displayed the most potent antiproliferative activity against MGC-803 cells with IC50 value of 20.0 μM. Preliminary mechanistic studies… read more here.
Keywords: amino acid; mgc 803; acid derivatives; cell ... See more keywords
Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology reports"
DOI: 10.3892/or.2017.6028
Abstract: Curcumol, a polyphenol compound derived from the rhizome of Curcuma, has been established as an antitumor compound against multiple types of cancer, including gastric (GC), lung, liver and breast cancer. However, the molecular mechanisms undelying its… read more here.
Keywords: curcumol; adenocarcinoma mgc; mgc 803; gastric adenocarcinoma ... See more keywords