No Effect of PXR (8055C>T) Polymorphism on the Pharmacokinetic Profiles of Piperaquine in Healthy Chinese Subjects.
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DOI: 10.2174/1389200223666220215151945
Abstract: BACKGROUND Significant inter-subject variability in pharmacokinetics and clinical outcomes has been observed for the antimalarial agent piperaquine (PQ). PQ is metabolized by CYP3A4, mainly regulated by pregnane X receptor (PXR). CYP3A4(*1B) polymorphism did not affect… read more here.
Keywords: 8055c polymorphism; pxr 8055c; effect pxr; pharmacokinetic profiles ... See more keywords