H3B-8800-G0001-101: A first in human phase I study of a splicing modulator in patients with advanced myeloid malignancies.
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DOI: 10.1200/jco.2017.35.15_suppl.tps7075
Abstract: TPS7075Background: Dysregulated mRNA splicing is important in tumorigenesis and in resistance to cancer therapy. Somatic heterozygous mutations in core spliceosome genes (e.g. SF3B1, SRSF2, U2AF1) have been reported at high frequencies in patients with myelodysplastic… read more here.
Keywords: h3b 8800; g0001 101; first human; 101 first ... See more keywords