Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET
Sign Up to like & getrecommendations! Published in 2024 at "EJNMMI Research"
DOI: 10.1186/s13550-024-01079-5
Abstract: Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89Zr-mAb uptake on PET. Target-specific binding in tumours is of main interest; however, non-specific irreversible uptake may also be present,… read more here.
Keywords: immuno pet; 89zr immuno; target negative; negative tumours ... See more keywords
The tumor targeting performance of anti-CD166 Probody drug conjugate CX-2009 and its parental derivatives as monitored by 89Zr-immuno-PET in xenograft bearing mice
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DOI: 10.7150/thno.44334
Abstract: Probody® therapeutics are recombinant masked monoclonal antibody (mAb) prodrugs that become activated by proteases present in the tumor microenvironment. This makes them attractive for use as Probody drug conjugates (PDCs). CX-2009 is a novel PDC… read more here.
Keywords: probody; drug; tumor targeting; 89zr immuno ... See more keywords