Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1).
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DOI: 10.1021/acs.jmedchem.0c00978
Abstract: Histone demethylase LSDl (KDMlA) belongs to the flavin adenine dinucleotide (FAD) dependent family of monoamine oxidases and is vital in regulation of mammalian biology. Dysregulation and overexpression of LSD1 are hallmarks of a number of… read more here.
Keywords: potent selective; discovery 90011; demethylase; selective reversible ... See more keywords