99mTc-Labeled Quinolone-Based Novel Skeletal Tracers for Tumor Visualization through Fibroblast Activation Protein.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c00132
Abstract: Fibroblast activation protein (FAP) has emerged as a prominent target for tumor diagnosis. Quinoline-based FAP PET tracers demonstrated clinical feasibility. However, there is a relative scarcity of clinical studies on 99mTc-labeled FAP SPECT tracers. The… read more here.
Keywords: quinolone based; 99mtc fapi; fibroblast activation; 99mtc labeled ... See more keywords
A Simple Kit Formulation for Preparation and Exploratory Human Studies of a Novel 99mTc-Labeled Fibroblast Activation Protein Inhibitor Tracer for Imaging of the Fibroblast Activation Protein in Cancers.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c01094
Abstract: Fibroblast activation protein (FAP) is a potential target for tumor diagnosis and treatment because it is selectively expressed on the cell membrane of cancer-associated fibroblasts in most solid tumor stroma. The aim of this study… read more here.
Keywords: activation protein; 99mtc fapi; fibroblast activation; 99mtc labeled ... See more keywords
Comparison of [99mTc]Tc-FAPI SPECT/CT and [18F]FDG PET/CT as predictive biomarkers for immunotherapy response in gastrointestinal cancer
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DOI: 10.1038/s41598-025-01577-z
Abstract: To explore the diagnostic performance of [99mTc]Tc-FAPI SPECT/CT for gastrointestinal cancer, compared to [18F]FDG PET/CT. In this analysis of a prospective trial, consecutively recruited patients from a single center with pathologically confirmed gastrointestinal cancer were… read more here.
Keywords: fapi spect; fdg pet; 99mtc fapi; 18f fdg ... See more keywords
A Case of Metastatic Pulmonary Calcification Detected on 99mTc-MDP Bone Scan and 99mTc-FAPI Scan.
Sign Up to like & getrecommendations! Published in 2024 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000005321
Abstract: ABSTRACT A 59-year-old woman with recent history of weakness, loss of appetite, and significant weight loss was referred for malignancy workup. On the first day, the patient underwent a 99mTc-MDP scan, which revealed diffuse pulmonary… read more here.
Keywords: 99mtc fapi; fapi scan; metastatic pulmonary; case ... See more keywords
Utilizing 99mTc-FAPI-46 SPECT/CT in Detection of Peritoneal Carcinomatosis in Gastric Poorly Differentiated Adenocarcinoma: A Case Report.
Sign Up to like & getrecommendations! Published in 2024 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000005554
Abstract: ABSTRACT We introduce a 61-year-old man with poorly differentiated gastric adenocarcinoma, who previously underwent surgical treatment. In this presentation, he complained of a newly appeared midabdominal mass after the latest chemotherapy session. He was a… read more here.
Keywords: fapi spect; report; 99mtc fapi; utilizing 99mtc ... See more keywords
Pulmonary Lymphangitis Carcinomatosis in Rapid Progressive Recurrent Pheochromocytoma: A Case Exhibiting the Peer Diagnostic Value of 99mTc-FAPI-46 and 99mTc-HYNIC-Octreotide Scans.
Sign Up to like & getrecommendations! Published in 2025 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000005710
Abstract: A 43-year-old woman with a history of left adrenal pheochromocytoma was suspected for recurrence 2 months after adrenalectomy. Imaging assessments revealed metastatic lesions in the lungs and abdominal lymph nodes. Despite initial treatment with long-acting… read more here.
Keywords: 99mtc hynic; 99mtc fapi; pulmonary lymphangitis; hynic octreotide ... See more keywords
Metastasis Workup for Alveolar Paratesticular Rhabdomyosarcoma: 18F-FDG PET/CT Versus 99mTc-FAPI-46 SPECT/CT.
Sign Up to like & getrecommendations! Published in 2025 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000005738
Abstract: We present a 19-year-old man with alveolar paratesticular rhabdomyosarcoma (RMS) who underwent restaging with both 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/ computed tomography (CT) and 99mTc-fibroblast activation protein inhibitor (FAPI)-46 single-photon emission computed tomography (SPECT)/CT after… read more here.
Keywords: 18f fdg; fdg pet; fapi spect; 99mtc fapi ... See more keywords
Remarkable 99mTc-FAPI-46 Uptake in a Patient With Anaplastic Thyroid Carcinoma: A Promising Step in Theranostic Field.
Sign Up to like & getrecommendations! Published in 2025 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000005746
Abstract: Fibroblast activation protein (FAP)-targeted radionuclides are known as a promising step in cancer diagnosis and treatment (theranostic), although it is still a subject under investigation. We present a patient with anaplastic thyroid carcinoma who underwent… read more here.
Keywords: fapi uptake; promising step; anaplastic thyroid; 99mtc fapi ... See more keywords
Enhancing Initial Staging of a Gastric Cancer Patient: The Advantage of [99mTc]-FAPI-46 SPECT/CT Over Conventional CT.
Sign Up to like & getrecommendations! Published in 2025 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000005794
Abstract: We present a 59-year-old man with gastric signet-ring cell carcinoma, initially staged with contrast-enhanced CT (CECT), revealing gastric wall thickening, lymph nodes, and lung metastases. Subsequently, [99mTc]-FAPI-46 SPECT/CT demonstrated increased tracer uptake in the gastric… read more here.
Keywords: 99mtc fapi; fapi spect; gastric cancer; staging gastric ... See more keywords
Comparable Diagnostic Value of 99mTc-FAPI-46 SPECT/CT and 18F-FDG PET/CT in Cholangiocarcinoma: A Case Report.
Sign Up to like & getrecommendations! Published in 2025 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000005877
Abstract: We describe a 51-year-old man with cholangiocarcinoma of the common bile duct. Initially deemed nonmetastatic, he was a candidate for curative surgery and liver transplantation. However, during laparotomy, peritoneal seeding was discovered, necessitating omentectomy and… read more here.
Keywords: fapi spect; fdg pet; 99mtc fapi; 18f fdg ... See more keywords
99mTc-FAPI-46 Uptake in Medication-Related Jaw Osteonecrosis.
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DOI: 10.1097/rlu.0000000000005952
Abstract: We present a case of a 58-year-old woman with a history of breast cancer who developed medication-related osteonecrosis of the jaw following a dental extraction. Notably, a 99mTc-FAPI-46 scintigraphy revealed increased FAPI uptake at the… read more here.
Keywords: fapi uptake; medication related; 99mtc fapi; jaw osteonecrosis ... See more keywords