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Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01853
Abstract: For over 40 years, none of the previous 99mTc-labeled fatty acids for myocardial imaging has potential clinical use. 99mTc-(C10-6-thia-CO2H)(MIBI)5 is the first 99mTc-labeled fatty acid to exhibit good myocardial uptake (2.06 ± 0.06%ID/g) at 60…
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Keywords:
99mtc c10;
mibi;
min;
99mtc labeled ... See more keywords
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2
Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02062
Abstract: Fibroblast activation protein (FAP) is a potential target for tumor diagnosis and treatment due to its selective expression on cancer-associated fibroblasts (CAFs) in most solid tumor stroma. Two FAP inhibitor (FAPI) derived ligands (L1 and…
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Keywords:
fibroblast activation;
99mtc labeled;
tumor;
evaluation 99mtc ... See more keywords
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Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c01094
Abstract: Fibroblast activation protein (FAP) is a potential target for tumor diagnosis and treatment because it is selectively expressed on the cell membrane of cancer-associated fibroblasts in most solid tumor stroma. The aim of this study…
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Keywords:
activation protein;
99mtc fapi;
fibroblast activation;
99mtc labeled ... See more keywords
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Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b03167
Abstract: In recent years, cardiac glycosides (CGs) have been investigated as potential antiviral and anticancer drugs. Digitoxigenin (DIG) and other CGs have been shown to bind and inhibit Na+/K+-adenosinetriphosphatase (ATPase). Tumor cells show a higher expression…
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Keywords:
atpase;
99mtc labeled;
compound;
cancer ... See more keywords
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Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-70991-2
Abstract: The work considers the problem of obtaining nanocolloid radiopharmaceuticals (RPs) and studying their functional suitability for diagnosing sentinel lymph nodes (SLN) in cancer patients. Two principal approaches to the formation of technetium-99m-labeled particles based on…
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Keywords:
nanocolloid drugs;
labeled nanocolloid;
99mtc labeled;
drugs development ... See more keywords
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Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra04311j
Abstract: The difference in 2-proton's acidity between Lβ and LG led to dramatically different results of their reactions with [99mTc][Tc(CO)3(OH2)3]+.
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Keywords:
99mtc labeled;
labeled tetravalent;
tetravalent targeting;
synthesis 99mtc ... See more keywords
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Published in 2017 at "Journal of Veterinary Internal Medicine"
DOI: 10.1111/jvim.14673
Abstract: Background Diagnosis of protein loss into the gastrointestinal tract using noninvasive techniques is challenging. In people, scintigraphy not only is a sensitive tool to confirm protein‐losing enteropathy (PLE), but it also allows for localization of…
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Keywords:
protein losing;
scintigraphy;
losing enteropathy;
99mtc labeled ... See more keywords
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0
Published in 2019 at "EJNMMI Research"
DOI: 10.1186/s13550-019-0584-8
Abstract: PurposeWe aimed to compare different methods for semi-quantitative analysis of cardiac retention of bone tracers in patients with cardiac transthyretin amyloidosis (ATTR).MethodsData from 67 patients with ATTR who underwent both conventional whole-body scan and a…
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Keywords:
uptake;
cardiac retention;
99mtc labeled;
bone ... See more keywords
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Published in 2023 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-023-02533-8
Abstract: Infectious diseases are still the major issue not only due to antibiotic resistance but also causing deaths if not diagnosed at early-stages. Different approaches including nanosized drug delivery systems and theranostics are researched to overcome…
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Keywords:
labeled colistin;
colistin encapsulated;
pseudomonas aeruginosa;
liposome formulations ... See more keywords
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Published in 2019 at "Radiochimica Acta"
DOI: 10.1515/ract-2019-3156
Abstract: Abstract To assess the suitability of 99mTc labeled 5α-reductase (5α-Rds) inhibitors for non-invasive targeting of prostate cancer (PCa) using Male Sprague Dawely Rat (MSDR) model. In this work, dutasteride (Cpd-1) a 5α-Rds inhibitor was derivatized…
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Keywords:
cpd;
reductase;
target;
99mtc labeled ... See more keywords
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2
Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14050996
Abstract: Certain receptors are often overexpressed during tumor occurrence and development and closely correlate with carcinogenesis. Owing to its overexpression on the cell membrane and cytoplasm of various tumors, plectin, which is involved in tumor proliferation,…
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Keywords:
tumor imaging;
spect probe;
99mtc labeled;
plectin ... See more keywords