High‐level production of wild‐type and oxidation‐resistant recombinant alpha‐1‐antitrypsin in glycoengineered CHO cells
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DOI: 10.1002/bit.28129
Abstract: Alpha‐1‐antitrypsin (A1AT) is a serine protease inhibitor which blocks the activity of serum proteases including neutrophil elastase to protect the lungs. Its deficiency is known to increase the risk of pulmonary emphysema as well as… read more here.
Keywords: oxidation; alpha antitrypsin; a1at; cho cells ... See more keywords
Identification of carbamylated alpha 1 anti-trypsin (A1AT) as an antigenic target of anti-CarP antibodies in patients with rheumatoid arthritis.
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DOI: 10.1016/j.jaut.2017.02.008
Abstract: In 2011 a novel autoantibody system, anti-carbamylated protein (anti-CarP) antibodies, was described in rheumatoid arthritis (RA) patients. Anti-CarP antibody positivity associates with a more severe disease course, is observed years before disease onset, and may… read more here.
Keywords: carp antibodies; anti carp; rheumatoid arthritis; target anti ... See more keywords
Role of the P2 residue of human alpha 1-antitrypsin in determining target protease specificity
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DOI: 10.1371/journal.pone.0185074
Abstract: Alpha 1-antitrypsin (A1AT) is a serine protease inhibitor that mainly inhibits neutrophil elastase in the lungs. A variant of A1AT at the P1 position with methionine 358 to arginine (A1AT-Pittsburgh) is a rapid inhibitor of… read more here.
Keywords: alpha antitrypsin; role residue; role; a1at ... See more keywords
Alpha-1 Antitrypsin-Induced Endoplasmic Reticulum Stress Promotes Invasion by Extravillous Trophoblasts
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DOI: 10.3390/ijms22073683
Abstract: Alpha-1 antitrypsin (A1AT) is a glycoprotein that has been shown to protect tissues from proteolytic damage under various inflammatory conditions. Several studies show that A1AT may be associated with pre-eclampsia. However, the role of A1AT… read more here.
Keywords: endoplasmic reticulum; alpha antitrypsin; reticulum stress; stress ... See more keywords