The mechanism study of YZG-331 on sedative and hypnotic effects
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2022.113885
Abstract: YZG-331 is a synthetic novel derivates of N6-(4-hydroxybenzyl) adenine riboside (NHBA), which has potent sedative and hypnotic effects based on our previous study. We are now aiming to investigate the mechanism of YZG-331. In this… read more here.
Keywords: sedative hypnotic; study; yzg 331; mechanism ... See more keywords
Adenosine A2AR/A1R Antagonists Enabling Additional H3R Antagonism for the Treatment of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00914
Abstract: Adenosine A1/A2A receptors (A1R/A2AR) represent targets in nondopaminergic treatment of motor disorders such as Parkinson's disease (PD). As an innovative strategy, multitargeting ligands (MTLs) were developed to achieve comprehensive PD therapies simultaneously addressing comorbid symptoms… read more here.
Keywords: treatment; a1r a2ar; parkinson disease; h3r ... See more keywords
Adenosine receptor stimulation inhibits methamphetamine-associated cue seeking
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811221147157
Abstract: Background: Methamphetamine (METH) is a psychostimulant drug that remains a popular and threatening drug of abuse with high abuse liability. There is no established pharmacotherapy to treat METH dependence, but evidence suggests that stimulation of… read more here.
Keywords: cue; a1r a2ar; stimulation; adenosine receptor ... See more keywords
Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain
Sign Up to like & getrecommendations! Published in 2018 at "BMC Biology"
DOI: 10.1186/s12915-018-0491-x
Abstract: BackgroundG-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A1R or A2AR) can form A1R-A2AR heteromers (A1-A2AHet), and their activation leads to canonical G-protein-dependent (adenylate… read more here.
Keywords: a2ar; protein coupled; coupled receptor; a1r a2ar ... See more keywords