Discovery and Structure–Activity Relationship Studies of Novel Adenosine A1 Receptor-Selective Agonists
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DOI: 10.1021/acs.jmedchem.2c01414
Abstract: A series of benzyloxy and phenoxy derivatives of the adenosine receptor agonists N6-cyclopentyl adenosine (CPA) and N6-cyclopentyl 5′-N-ethylcarboxamidoadenosine (CP-NECA) were synthesized, and their potency and selectivity were assessed. We observed that the most potent were… read more here.
Keywords: structure activity; discovery structure; a1r selectivity; adenosine receptor ... See more keywords