A20 restores phorbol ester‐induced differentiation of THP‐1 cells in the absence of nuclear factor‐κB activation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26308
Abstract: A20, also referred to as tumor necrosis factor alpha (TNFα)‐induced protein 3 (TNFAIP3), is an ubiquitin‐editing enzyme whose expression is enhanced by NF‐κB activation, and plays an important role in silencing NF‐κB activity. Another well‐known… read more here.
Keywords: expression; differentiation; a20; activity ... See more keywords
Calcitriol Ameliorates AngiotensinII-Induced Renal Injury Partly via Upregulating A20
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0629-y
Abstract: Inflammation and reactive oxygen species (ROS) play crucial roles in the progression of chronic kidney diseases. Vitamin D has been shown anti-inflammatory effects, but the underlying mechanism is not fully understood. Here, we investigated whether… read more here.
Keywords: calcitriol; renal injury; a20; induced renal ... See more keywords
Haploinsufficiency of A20 Due to Novel Mutations in TNFAIP3
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-020-00792-9
Abstract: Haploinsufficiency of A20 (HA20) is a newly described immune dysregulation disease due to the loss-of-function mutation in TNFAIP3. In the present study, we report six patients from four unrelated Chinese families with distinct pathogenic mutations… read more here.
Keywords: a20 due; due novel; a20; haploinsufficiency a20 ... See more keywords
Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.06.014
Abstract: Although recent progress provides mechanistic insights into the pathogenesis of pulmonary fibrosis (PF), rare anti-PF therapeutics show definitive promise for treating this disease. Repeated lung epithelial injury results in injury-repairing response and inflammation, which drive… read more here.
Keywords: ubiquitin editing; degradation; transcription factor; a20 ... See more keywords
Haploinsufficiency of A20 impairs protein–protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation
Sign Up to like & getrecommendations! Published in 2018 at "RMD Open"
DOI: 10.1136/rmdopen-2018-000740
Abstract: Objectives TNFAIP3 encodes A20 that negatively regulates nuclear factor kappa light chain enhancer of activated B cells (NF-κB), the major transcription factor coordinating inflammatory gene expression. TNFAIP3 polymorphisms have been linked with a spectrum of… read more here.
Keywords: inflammasome activation; protein protein; a20; haploinsufficiency a20 ... See more keywords
A20 Is Increased in Fetal Lung in a Sheep LPS Model of Chorioamnionitis
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/6421419
Abstract: Chorioamnionitis is associated with an increased risk of preterm birth and aggravates adverse outcomes such as BPD. Development of BPD is associated with chronic inflammatory reactions and oxidative stress in the airways which may be… read more here.
Keywords: proinflammatory cytokines; chorioamnionitis; fetal lung; a20 ... See more keywords
Abstract 5028: The regulation of inflammatory signaling in cancer via A20 phosphorylation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5028
Abstract: A20 is an anti-inflammatory protein with a dual ubiquitin-editing activity. Through its N-terminal ovarian tumor (OTU) domain, A20 negatively regulates NF-ĸB by removing the K63-linked ubiquitin chains on RIP1 that act as platforms for NF-ĸB… read more here.
Keywords: a20; a20 phosphorylation; activity; regulation inflammatory ... See more keywords
Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Innate Immunity"
DOI: 10.1159/000527624
Abstract: The correlation between ubiquitin-editing enzyme A20 and E3 ubiquitin ligase ring finger protein (RNF) 168 has been reported to be critical for repair of DNA damage. This study aimed to evaluate the potential role of… read more here.
Keywords: editing enzyme; a20; ubiquitin editing; rnf168 ... See more keywords
A20 Establishes Negative Feedback With TRAF6/NF-κB and Attenuates Early Brain Injury After Experimental Subarachnoid Hemorrhage
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.623256
Abstract: Nuclear factor (NF)-κB–ty -50mediated neuroinflammation plays a crucial role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). As an important negative feedback regulator of NF-κB, A20 is essential for inflammatory homeostasis. Herein, we tested… read more here.
Keywords: traf6; expression; a20; brain ... See more keywords
ALKBH5-Mediated m6A Modification of A20 Regulates Microglia Polarization in Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.813979
Abstract: Background To investigate the role of microglia polarization in the pathogenesis of diabetic retinopathy, and study the mechanism of ALKBH5-mediated m6A modification of A20 of retinal microglia polarization. Methods Diabetics rats were constructed and the… read more here.
Keywords: m6a modification; a20; microglia polarization; polarization ... See more keywords
Differential Engraftment of Parental A20 PD-L1 WT and PD-L1 KO Leukemia Cells in Semiallogeneic Recipients in the Context of PD-L1/PD-1 Interaction and NK Cell-Mediated Hybrid Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.887348
Abstract: The contribution of natural killer (NK) cells to tumor rejection in the context of programmed death-ligand 1/programmed death 1 (PD-L1/PD-1) blockade is a matter of intense debate. To elucidate the role of PD-L1 expression on… read more here.
Keywords: a20; tumor cells; expression; tumor ... See more keywords