tPA variant tPA‐A296–299 Prevents impairment of cerebral autoregulation and necrosis of hippocampal neurons after stroke by inhibiting upregulation of ET‐1
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DOI: 10.1002/jnr.24112
Abstract: Tissue‐type plasminogen activator (tPA) is neurotoxic and exacerbates uncoupling of cerebral blood flow (CBF) and metabolism after stroke, yet it remains the sole FDA‐approved drug for treatment of ischemic stroke. Upregulation of c‐Jun‐terminal kinase (JNK)… read more here.
Keywords: autoregulation; a296 299; autoregulation necrosis; tpa ... See more keywords