Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A2A/A2B adenosine receptor antagonists
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DOI: 10.1080/14756366.2022.2077731
Abstract: Abstract A series of novel dual A2A/A2B AR antagonists based on the triazole-pyrimidine-methylbenzonitrile core were designed and synthesised. The A2A AR antagonist cAMP functional assay results were encouraging for most target compounds containing quinoline or… read more here.
Keywords: a2a a2b; dual a2a; pyrimidine methylbenzonitrile; triazole pyrimidine ... See more keywords