Sinomenine increases adenosine A2A receptor and inhibits NF‐κB to inhibit arthritis in adjuvant‐induced‐arthritis rats and fibroblast‐like synoviocytes through α7nAChR
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ma0121-024rrrr
Abstract: Sinomenine (SIN) is a clinical drug for treating rheumatoid arthritis (RA) in China. Our previous study found SIN inhibited inflammation via alpha7 nicotinic acetylcholine receptor (α7nAChR) in macrophages in vitro. Adenosine receptor A2A has anti‐inflammatory… read more here.
Keywords: a2a receptor; adenosine a2a; sin; arthritis ... See more keywords
Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson’s disease mice model
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03670-0
Abstract: Parkinson’s disease (PD) is the second common age-related neurodegenerative disease. It is characterized by control loss of voluntary movements control, resting tremor, postural instability, bradykinesia, and rigidity. The aim of the present work is to… read more here.
Keywords: curcumin niacin; adenosine a2a; a2a receptor; parkinson disease ... See more keywords
Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02275-9
Abstract: Angelman syndrome (AS) is a neurogenetic disorder involving ataxia and motor dysfunction, resulting from the absence of the maternally inherited functional Ube3a protein in neurons. Since adenosine A2A receptor (A2AR) blockade relieves synaptic and motor… read more here.
Keywords: adenosine a2a; a2a receptor; blockade; angelman syndrome ... See more keywords
Adenosine and the Cardiovascular System
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Cardiovascular Drugs"
DOI: 10.1007/s40256-019-00345-5
Abstract: Adenosine is an endogenous nucleoside with a short half-life that regulates many physiological functions involving the heart and cardiovascular system. Among the cardioprotective properties of adenosine are its ability to improve cholesterol homeostasis, impact platelet… read more here.
Keywords: a2a receptor; cholesterol; platelet; receptor ... See more keywords
Adenosine A2A receptor blockade attenuates spatial memory deficit and extent of demyelination areas in lyolecithin‐induced demyelination model
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.05.007
Abstract: &NA; In recent years, inactivation of A2A adenosine receptors has been emerged as a novel strategy for treatment of several neurodegenerative diseases. Although numerous studies have shown the beneficial effects of A2A receptors blockade on… read more here.
Keywords: demyelination; spatial memory; adenosine a2a; a2a receptor ... See more keywords
Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.10.022
Abstract: &NA; Insomnia is one of the most common sleep problems with an estimated prevalence of 10%–15% in the general population. Although adenosine A2A receptor (A2AR) agonists strongly induce sleep, their cardiovascular effects preclude their use… read more here.
Keywords: adenosine a2a; a2a receptor; wave sleep; a2ar pam ... See more keywords
Ethanol Intake and A2A Receptor Overexpression.
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.08.030
Abstract: Preclinical data indicate that ethanol produces behavioral effects that can be regulated by many neurotransmitters and neuromodulators like adenosine (A). The most important receptors with respect to the rewarding effects of ethanol seem to be… read more here.
Keywords: receptor; ethanol consumption; a2a receptor; overexpression ... See more keywords
Adenosine A2A Receptor Antagonists for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00237
Abstract: Currently, the most promising therapeutic modality for cancer treatment is the blockade of immune checkpoint pathways, which has revolutionized cancer therapy in the last 15 years. Strategies targeting and modulating adenosine A2A receptor (A2AR), an… read more here.
Keywords: cancer; adenosine a2a; a2a receptor;
Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8H)-one Derivatives as Novel Potent Adenosine A2A Receptor Antagonists for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02199
Abstract: In recent years, the adenosine A2A receptor (A2AR) has shown exciting progress in the development of immunotherapies for the treatment of cancer. Herein, a 2-amino-7,9-dihydro-8H-purin-8-one compound (1) was identified as an A2AR antagonist hit through… read more here.
Keywords: antagonists cancer; adenosine a2a; one derivatives; aminopteridin one ... See more keywords
In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.6b12830
Abstract: Cell transmembrane receptors play a key role in the detection of environmental stimuli and control of intracellular communication. G protein-coupled receptors constitute the largest transmembrane protein family involved in cell signaling. However, current methods for… read more here.
Keywords: reconstitution adenosine; adenosine a2a; a2a receptor; reconstitution ... See more keywords
Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-021-01238-5
Abstract: In fragile X syndrome (FXS) the lack of the fragile X mental retardation protein (FMRP) leads to exacerbated signaling through the metabotropic glutamate receptors 5 (mGlu5Rs). The adenosine A 2A receptors (A 2A Rs), modulators… read more here.
Keywords: fmr1 mice; inhibition reduces; receptor inhibition; adenosine a2a ... See more keywords