Selective block of adenosine A2A receptors prevents ischaemic‐like effects induced by oxygen and glucose deprivation in rat medium spiny neurons
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15922
Abstract: Ischaemia is known to cause massive neuronal depolarization, termed anoxic depolarization (AD), due to energy failure and loss of membrane ion gradients. The neuromodulator adenosine accumulates extracellularly during ischaemia and activates four metabotropic receptors: A1,… read more here.
Keywords: a2a receptors; block adenosine; spiny neurons; medium spiny ... See more keywords
Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.666710
Abstract: Astrocytes, through their numerous processes, establish a bidirectional communication with neurons that is crucial to regulate synaptic plasticity, the purported neurophysiological basis of memory. This evidence contributed to change the classic “neurocentric” view of Alzheimer’s… read more here.
Keywords: astrocytes adenosine; alzheimer disease; adenosine a2a; disease ... See more keywords
Increased Density of Endogenous Adenosine A2A Receptors in Atrial Fibrillation: From Cellular and Porcine Models to Human Patients
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043668
Abstract: Adenosine, an endogenous nucleoside, plays a critical role in maintaining homeostasis during stressful situations, such as energy deprivation or cellular damage. Therefore, extracellular adenosine is generated locally in tissues under conditions such as hypoxia, ischemia,… read more here.
Keywords: a2a receptors; density; adenosine; adenosine a2a ... See more keywords