Adenosine A2A receptor involves in neuroinflammation-mediated cognitive decline through activating microglia under acute hypobaric hypoxia
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.02.038
Abstract: HighlightsAcute HH induced cognitive impairments and neuroinflammation in the hippocampus.Genetic A2AR deletion attenuated acute HH‐induced impairment of spatial memory.Hippocampal A2ARs were mainly expressed on microglia and up‐regulated in acute HH model of mice.Microglia‐mediated neuroinflammation by… read more here.
Keywords: a2ar; spatial memory; adenosine a2a; hypobaric hypoxia ... See more keywords
Pharmacological targeting of immune checkpoint A2aR improves function of anti-CD19 CAR T cells in vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Immunology letters"
DOI: 10.1016/j.imlet.2020.04.005
Abstract: In spite of impressive results in the treatment of acute lymphoblastic B cell leukemia (B-ALL) with chimeric antigen receptor (CAR) T cells, the clinical outcome of some hematological cancers like follicular lymphoma (FL) and chronic… read more here.
Keywords: a2ar; anti cd19; pharmacological targeting; car cells ... See more keywords
Angiotensin II type 1/adenosine A2A receptor oligomers: a novel target for tardive dyskinesia
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02037-z
Abstract: Tardive dyskinesia (TD) is a serious motor side effect that may appear after long-term treatment with neuroleptics and mostly mediated by dopamine D2 receptors (D2Rs). Striatal D2R functioning may be finely regulated by either adenosine… read more here.
Keywords: at1r a2ar; a2ar; adenosine a2a; receptor ... See more keywords
Native adenosine A2A receptor solubilisation by a library of amphipathic copolymers.
Sign Up to like & getrecommendations! Published in 2025 at "Biomaterials science"
DOI: 10.1039/d5bm01011j
Abstract: Polymer nanodiscs are a research tool that allows membrane proteins (MPs) to be encapsulated by a surrounding amphipathic polymer, isolated and studied to understand their structural and physiological properties. An advantage of using polymer nanodiscs… read more here.
Keywords: kspma tmaema; a2ar; solubilisation; poly mvp ... See more keywords
Macrophage A2aR Alleviates LPS‐Induced Vascular Endothelial Injury and Inflammation via Inhibiting M1 Polarisation and Oxidative Stress
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70458
Abstract: Vascular inflammation and endothelial dysfunction secondary to unchecked activation of endothelium are key mechanisms underlying sepsis and organ failure. However, the intrinsic processes that mitigate excessive endothelial cell activation remain incompletely understood. To determine the… read more here.
Keywords: vascular endothelial; a2ar; induced vascular; lps induced ... See more keywords
Inhibition of visceral adipose tissue-derived pathogenic signals by activation of adenosine A2AR improves hepatic and cardiac dysfunction of NASH mice
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Physiology - Gastrointestinal and Liver Physiology"
DOI: 10.1152/ajpgi.00104.2023
Abstract: A2AR-disrupted mice is characterized by severe systemic and visceral adipose tissue (VAT) inflammation. Increasing adenosine cyclase (AC), cAMP and protein kinase A (PKA) formation through A2AR activation suppress systemic/VAT inflammation in obese mice. This study… read more here.
Keywords: cardiac dysfunction; mice; a2ar; hepatic cardiac ... See more keywords
Abstract 4572: Characterization of the potent and selective A2aR antagonist AB928 for the treatment of cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4572
Abstract: Introduction: In the tumor micro-environment, extracellular ATP is sequentially hydrolyzed to adenosine by the ecto-nucleotidases CD39 (ATP→AMP) and CD73 (AMP→adenosine). Adenosine, through activation of the A2a receptor (A2aR), is a potent inhibitor of T-cell activation,… read more here.
Keywords: potent selective; a2ar; activation; antagonist ... See more keywords
Abstract 3768: Identification of a novel non-brain penetrant A2AR inhibitor and proof-of-concept of CD73 and A2AR/CD73 small-molecule inhibitors for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3768
Abstract: Adenosine, generated by CD73 is a key driver of immunosuppression in the hypoxic tumour microenvironment (TME). In immune-inflamed tumours, with CD8+ T-cell infiltrates, adenosine signalling is a cause of resistance to immune checkpoint therapies (ICTs)… read more here.
Keywords: a2ar; small molecule; novel non; cd73 ... See more keywords
Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain
Sign Up to like & getrecommendations! Published in 2018 at "BMC Biology"
DOI: 10.1186/s12915-018-0491-x
Abstract: BackgroundG-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A1R or A2AR) can form A1R-A2AR heteromers (A1-A2AHet), and their activation leads to canonical G-protein-dependent (adenylate… read more here.
Keywords: a2ar; protein coupled; coupled receptor; a1r a2ar ... See more keywords
Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer"
DOI: 10.1186/s12943-017-0665-0
Abstract: BackgroundCancer immunotherapy offers a promising approach in cancer treatment. The adenosine A2A receptor (A2AR) could protect cancerous tissues from immune clearance via inhibiting T cells response. To date, the role of A2AR in head and… read more here.
Keywords: response; a2ar; adenosine a2a; blockade ... See more keywords
Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2018.00043
Abstract: Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or extracellularly, and acts as a neuromodulator. It operates as a volume transmission signal through diffusion and flow in the extracellular space to… read more here.
Keywords: adenosine a2ar; heteroreceptor complexes; a2ar heteroreceptor; a2ar ... See more keywords