Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2017.03.003
Abstract: &NA; Adenosine 2A receptor (A2AR) agonists were indicated to reduce cocaine reward and cocaine seeking mainly through activation of antagonistic allosteric A2AR‐dopamine D2R (D2R) interactions in A2AR‐D2R heteroreceptor complexes. Furthermore, it was shown that modulation… read more here.
Keywords: d2r; accumbens shell; heteroreceptor complexes; a2ar d2r ... See more keywords
A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2018.10.007
Abstract: The concept of allosteric receptor-receptor interactions in G protein-coupled receptor homo- and heteroreceptor complexes in which they physically interact provides a new dimension to molecular integration in the brain. The receptor-receptor interactions dynamically change recognition,… read more here.
Keywords: receptor; heteroreceptor complexes; a2ar d2r; addiction ... See more keywords