Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4-/-/bco2-/- double knockout mice.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental eye research"
DOI: 10.1016/j.exer.2021.108680
Abstract: Accumulation of bisretinoids such as A2E and its isomer iso-A2E is thought to mediate blue light-induced oxidative damage associated with age-related macular degeneration (AMD) and autosomal recessive Stargardt disease (STGD1). We hypothesize that increasing dietary… read more here.
Keywords: a2e iso; iso a2e; a2e; bco2 ... See more keywords
The Effect of A2E on the Uptake and Release of Calcium in the Lysosomes and Mitochondria of Human RPE Cells Exposed to Blue Light
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Ophthalmology"
DOI: 10.1155/2021/5586659
Abstract: We aimed to explore the effect of N-retinylidene-N-retinylethanolamine (A2E) on the uptake and release of calcium in lysosomes and mitochondria by establishing a model of human retinal pigment epithelial (RPE) cell injury induced by exposure… read more here.
Keywords: blue light; rpe cells; a2e; lysosomes mitochondria ... See more keywords
NMDA Receptor Antagonists Degrade Lipofuscin via Autophagy in Human Retinal Pigment Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58081129
Abstract: Background and Objectives: Age-related macular degeneration is a slow-progressing disease in which lipofuscin accumulates in the retina, causing inflammation and apoptosis of retinal pigment epithelial (RPE) cells. This study aimed to identify N-methyl-D-aspartate (NMDA) signaling… read more here.
Keywords: nmda receptor; retinal pigment; a2e; arpe cells ... See more keywords