Alpha‐2‐macroglobulin in hemostasis and thrombosis: An underestimated old double‐edged sword
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15647
Abstract: Antiproteinases such as alpha‐2‐macroglobulin (A2M) play a role in hemostasis. A2M is highly conserved throughout evolution and is a high molecular weight homo‐tetrameric glycoprotein. A2M proteinase inhibitor activity is possible via a unique cage structure… read more here.
Keywords: hemostasis; a2m; hemostasis thrombosis; thrombosis ... See more keywords
The anti-tumorigenic activity of A2M—A lesson from the naked mole-rat
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0189514
Abstract: Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute… read more here.
Keywords: tumorigenic activity; anti tumorigenic; mole rat; naked mole ... See more keywords
Tissue specific alpha-2-Macroglobulin (A2M) splice isoform diversity in Hilsa shad, Tenualosa ilisha (Hamilton, 1822)
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DOI: 10.1371/journal.pone.0216144
Abstract: The present study, for the first time, reported twelve A2M isoforms in Tenualosa ilisha, through SMRT sequencing. Hilsa shad, T. ilisha, an anadromous fish, faces environmental stresses and is thus prone to diseases. Here, expression… read more here.
Keywords: splice; tissue specific; tenualosa ilisha; a2m ... See more keywords
Novel heterozygous mutation in alpha-2-macroglobulin (A2M) suppressing the binding of amyloid-β (Aβ)
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.1090900
Abstract: Introduction Many studies have suggested that the alpha-2-macroglobulin (A2M) gene may be involved in the pathogenesis of Alzheimer's disease (AD). A2M encoded by the A2M gene can specifically bind to the β-amyloid peptide and prevent… read more here.
Keywords: a2m; analysis; macroglobulin a2m; mutation ... See more keywords
Predictive Modeling of Thoracic Radiotherapy Toxicity and the Potential Role of Serum Alpha-2-Macroglobulin
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01395
Abstract: Background: To investigate the impact of alpha-2-macroglobulin (A2M), a suspected intrinsic radioprotectant, on radiation pneumonitis and esophagitis using multifactorial predictive models. Materials and Methods: Baseline A2M levels were obtained for 258 patients prior to thoracic… read more here.
Keywords: thoracic radiotherapy; baseline a2m; a2m; alpha macroglobulin ... See more keywords