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Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00416
Abstract: The aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) into fibrillary deposits is implicated in amyotrophic lateral sclerosis (ALS), and some hereditary mutations localized in the low complexity domain (LCD) facilitate the formation of…
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Keywords:
shaped protofilaments;
atomistic insights;
a315e mutation;
tdp ... See more keywords