A new imaging platform (iScreen) allows for the concurrent assessment of micronucleus induction and genotoxic mode of action in human A375 cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22496
Abstract: Genotoxicity testing guidelines require the assessment of the clastogenic and aneugenic potential of compounds. While in vitro micronucleus assays detect both types of endpoints, it requires labor‐intensive microscopic scoring and does not discriminate between the… read more here.
Keywords: imaging platform; platform; a375 cells; micronucleus induction ... See more keywords
Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib‐resistant melanoma cells by downregulating the EGFR signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23450
Abstract: Melanoma is a malignant tumor with aggressive behavior. Vemurafenib, a BRAF inhibitor, is clinically used in melanoma, but resistance to melanoma cytotoxic therapies is associated with BRAF mutations. Curcumin can effectively inhibit numerous types of… read more here.
Keywords: resistant melanoma; a375 cells; vemurafenib resistant; melanoma ... See more keywords
Zinc Oxide Nanoparticles Synthesized by Bacillus cereus PMSS-1 Induces Oxidative Stress-Mediated Apoptosis via Modulating Apoptotic Proteins in Human Melanoma A375 Cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cluster Science"
DOI: 10.1007/s10876-020-01941-1
Abstract: The microbial mediated synthesis of nanoparticles will be more effective for chemotherapeutic applications because microbes are well known attractive sources for the various biologically active biomolecules. The present study was designed to investigate the anticancer… read more here.
Keywords: melanoma; a375 cells; zno nps; oxide nanoparticles ... See more keywords
B7H6 silencing increases chemosensitivity to dacarbazine and suppresses cell survival and migration in cutaneous melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000890
Abstract: Cutaneous melanoma (CM) is a highly metastatic cancer whose incidence rate is heightening worldwide. B7H6, as one of the co-stimulatory ligands of the B7 family, is expressed in malignant cells, involved in tumorigenesis. This study… read more here.
Keywords: melanoma; a375 cells; b7h6; chemosensitivity ... See more keywords
Antitumor Effects of Extract of the Oak Bracket Medicinal Mushroom, Phellinus baumii (Agaricomycetes), on Human Melanoma Cells A375 In Vitro and In Vivo.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of medicinal mushrooms"
DOI: 10.1615/intjmedmushrooms.2020033687
Abstract: Melanoma is among the most aggressive and treatment-resistant human cancers. Phellinus baumii, a famous medicinal mushroom, has been used to treat different diseases, including cancer, in China and other east Asian countries. The purpose of… read more here.
Keywords: a375 cells; melanoma; phellinus baumii; medicinal mushroom ... See more keywords
Acetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling
Sign Up to like & getrecommendations! Published in 2021 at "OncoTargets and therapy"
DOI: 10.2147/ott.s308371
Abstract: Purpose This research aims to investigate the intervention and mechanism of 50% acetone extract of C. officinalis leaves (SZYY) on melanoma xenografts. Patients and Methods Tumor size and cardiac function were measured via ultrasound. The… read more here.
Keywords: officinalis leaves; anti melanoma; a375 cells; melanoma effects ... See more keywords
CDK5RAP1 targeting NF-κB signaling pathway in human malignant melanoma A375 cell apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.7920
Abstract: Malignant melanoma is characterized by rapid deterioration, early metastasis and high mortality. Cdk5 regulatory subunit-associated protein 1 (CDK5RAP1), which catalyzes 2-methylthio (ms2) modification of mitochondrial transfer RNAs, has been reported to induce cancer cell apoptosis,… read more here.
Keywords: apoptosis; a375 cells; cdk5rap1 deficiency; signaling pathway ... See more keywords