Two different kinds of interaction modes of deaminase APOBEC3A with single‐stranded DNA in solution detected by nuclear magnetic resonance
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4242
Abstract: APOBEC3A (A3A) deaminates deoxycytidine in target motif TC in a single‐stranded DNA (we termed it as TC DNA), which mortally mutates viral pathogens and immunoglobulins, and leads to the diversification and lethality of cancers. The… read more here.
Keywords: dna; stranded dna; two different; solution ... See more keywords
APOBEC3A Catalytic Inactivity Mutation Induces Tertiary Structure Destabilization.
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DOI: 10.1021/acsmedchemlett.2c00517
Abstract: APOBEC3A (A3A)-catalyzed DNA cytosine deamination is implicated in virus and cancer mutagenesis, and A3A is a target for small molecule drug discovery. The catalytic glutamic acid (E72) is frequently mutated in biochemical studies to characterize… read more here.
Keywords: a3a; apobec3a catalytic; inactivity mutation; mutation ... See more keywords
APOBEC3A regulates transcription from interferon-stimulated response elements
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2011665119
Abstract: Significance APOBEC3A (A3A) is a DNA binding enzyme that introduces mutations through its cytidine deaminase activity. In addition, A3A can repress proviral HIV-1 and retroelements within the host genome by a deaminase-independent mechanism. Here, we… read more here.
Keywords: a3a; apobec3a regulates; transcription interferon; stimulated response ... See more keywords