Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK directed activation of NF-κB
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DOI: 10.1038/s41388-020-01583-7
Abstract: The mutagenic APOBEC3B (A3B) cytosine deaminase is frequently over-expressed in cancer and promotes tumour heterogeneity and therapy resistance. Hence, understanding the mechanisms that underlie A3B over-expression is important, especially for developing therapeutic approaches to reducing… read more here.
Keywords: chemotherapy drugs; dna; a3b expression; expression ... See more keywords
B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers
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DOI: 10.1038/srep44089
Abstract: The key signature of cancer genomes is the accumulation of DNA mutations, the most abundant of which is the cytosine-to-thymine (C-to-T) transition that results from cytosine deamination. Analysis of The Cancer Genome Atlas (TCGA) database… read more here.
Keywords: induces apobec3b; myb induces; apobec3b expression; a3b ... See more keywords
APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression
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DOI: 10.1371/journal.pone.0223463
Abstract: Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) DNA cytosine deaminase 3B (A3B) is a DNA editing enzyme which induces genomic DNA mutations in multiple myeloma and in various other cancers. APOBEC family proteins are highly… read more here.
Keywords: reporter; dna damage; cell lines; expression ... See more keywords