Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK directed activation of NF-κB
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DOI: 10.1038/s41388-020-01583-7
Abstract: The mutagenic APOBEC3B (A3B) cytosine deaminase is frequently over-expressed in cancer and promotes tumour heterogeneity and therapy resistance. Hence, understanding the mechanisms that underlie A3B over-expression is important, especially for developing therapeutic approaches to reducing… read more here.
Keywords: chemotherapy drugs; dna; a3b expression; expression ... See more keywords