Enhancing the Catalytic Deamination Activity of APOBEC3C Is Insufficient to Inhibit Vif-Deficient HIV-1.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.03.015
Abstract: The retroviral restriction factors of the APOBEC3 (A3) cytidine deaminase family catalyze the deamination of cytidines in single-stranded viral DNA. APOBEC3C (A3C) is a strong antiviral factor against viral infectivity factor (vif)-deficient simian immunodeficiency virus… read more here.
Keywords: deamination; a3c; hiv; virus ... See more keywords
Divergence in dimerization and activity of primate APOBEC3C.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167306
Abstract: The APOBEC3 (A3) family of single-stranded DNA cytidine deaminases are host restriction factors that inhibit lentiviruses, such as HIV-1, in the absence of the Vif protein that causes their degradation. Deamination of cytidine in HIV-1… read more here.
Keywords: amino; dimerization; a3c; apobec3c ... See more keywords
Induction of APOBEC3C facilitates the genotoxic stress-mediated cytotoxicity of artesunate.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00358
Abstract: Artemisinin class of anticancer compounds is well-known for oxidative DNA damage-mediated growth arrest followed by cell death. However, the nature of this genotoxic stress for cancer therapeutics remains elusive. Here, we show that artesunate (Art),… read more here.
Keywords: dna damage; a3c; apobec3c; art ... See more keywords